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Table 1 Characteristics of study population

From: Cumulative dose of epinephrine and mode of death after non-shockable out-of-hospital cardiac arrest: a registry-based study

Variables

n (%) or mean ± SD

Alive

(n = 242)

Cardiocirculatory death

(n = 1,004)

Neurological death

(n = 1,233)

Other death

(n = 313)

p value

Chi2 or ANOVA

Missing data

Male

161 (66.5%)

628 (62.6%)

734 (59.5%)

179 (57.2%)

0.067

0 (0.0%)

Age (years)

61.2 ± 16.0

64.1 ± 14.9

61.6 ± 14.9

70.5 ± 15.7

 < 0.001

0 (0.0%)

Home location

152 (62.8%)

731 (72.9%)

876 (71.1%)

250 (80.1%)

 < 0.001

2 (0.1%)

Witnessed

212 (87.6%)

828 (82.8%)

998 (81.0%)

275 (87.9%)

0.006

5 (0.2%)

Bystander CPR

167 (69.6%)

597 (60.4%)

654 (53.2%)

193 (62.7%)

 < 0.001

26 (0.9%)

No-flow duration (min)

3.4 ± 5.5

6.1 ± 8.6

7.3 ± 8.2

5.9 ± 7.9

 < 0.001

409 (14.6%)

First recorded rhythm

      

 Asystole

 PEA

195 (80.6%)

47 (19.4%)

836 (83.3%)

168 (16.7%)

1058 (85.8%)

175 (14.2%)

272 (86.9%)

41 (13.1%)

0.072

0 (0.0%)

Epinephrine during CPR

      

 0 mg

 1 mg

 2–5 mg

 > 5 mg

90 (37.2%)

57 (23.6%)

83 (34.3%)

12 (5.0%)

43 (4.3%)

100 (10.0%)

575 (57.3%)

286 (28.5%)

72 (5.8%)

236 (19.1%)

750 (60.8%)

175 (14.2%)

38 (12.1%)

52 (16.6%)

178 (56.9%)

45 (14.4%)

 < 0.001

0 (0.0%)

Low-flow duration (min)

17.2 ± 15.6

36.2 ± 27.6

27.7 ± 17.4

26.7 ± 16.8

 < 0.001

315 (11.3%)

Heart disease

70 (28.9%)

274 (27.3%)

349 (28.3%)

114 (36.4%)

0.018

0 (0.0%)

Ischemic cardiopathy

32 (13.2%)

157 (15.7%)

172 (14.0%)

55 (17.6%)

0.31

0 (0.0%)

Cancer

27 (11.2%)

97 (9.7%)

135 (11.0%)

59 (18.9%)

0.001

0 (0.0%)

Renal disease

19 (7.9%)

76 (7.6%)

109 (8.8%)

37 (11.8%)

0.126

0 (0.0%)

High blood pressure

106 (43.8%)

399 (39.7%)

527 (42.7%)

147 (47.0%)

0.122

0 (0.0%)

Diabetes mellitus

49 (20.3%)

244 (24.3%)

272 (22.1%)

83 (26.5%)

0.195

0 (0.0%)

Dyslipidemia

48 (19.8%)

164 (16.3%)

208 (16.9%)

53 (16.9%)

0.635

0 (0.0%)

ECMO

Shock

ARDS

Refractory CA

15 (6.2%)

7 (46.7%)

0 (0.0%)

8 (53.3%)

134 (13.4%)

17 (12.7%)

0 (0.0%)

117 (87.3%)

60 (4.9%)

8 (13.3%)

1 (1.7%)

51 (85.0%)

21 (6.7%)

4 (19.0%)

0 (0.0%)

17 (81.0%)

 < 0.001

0 (0.0%)

Coronary angioplasty

36 (14.9%)

107 (10.7%)

91 (7.4%)

22 (7.0%)

 < 0.001

31 (1.1%)

TTM

122 (52.4%)

264 (26.8%)

628 (51.6%)

81 (26.7%)

 < 0.001

55 (2.0%)

Post-resuscitation shock

142 (62.6%)

761 (81.3%)

754 (64.4%)

185 (62.1%)

 < 0.001

160 (5.7%)

Presumed cause of CA

      

 Cardiac

 Non-cardiac

99 (40.9%)

143 (59.1%)

629 (62.7%)

375 (37.3%)

511 (41.4%)

722 (58.6%)

172 (55.0%)

141 (45.0%)

 < 0.001

0 (0.0%)

Details of non-cardiac causes

      

 Dyskalemia

 Pulmonary embolism

 Intracranial bleeding

 Asphyxia

 Drug overdose

 Other

6 (4.2%)

33 (23.1%)

2 (1.4%)

83 (58.0%)

4 (2.8%)

15 (10.5%)

14 (3.7%)

82 (21.9%)

25 (6.7%)

173 (46.1%)

1 (0.3%)

80 (21.3%)

28 (3.9%)

48 (6.6%)

181 (25.1%)

416 (57.6%)

6 (0.8%)

43 (6.0%)

6 (4.3%)

18 (12.8%)

14 (9.9%)

79 (56.0%)

0 (0.0%)

24 (17.0%)

 < 0.001

0 (0.0%)

  1. CPR, cardiopulmonary resuscitation; ALS, advanced life support; PEA, pulseless electrical activity; CA, cardiac arrest; ECMO, extracorporeal membrane oxygenation; TTM, targeted temperature management