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Table 2 Main outcomes of matched patients whether or not they received selective digestive decontamination

From: Association between selective digestive decontamination and decreased rate of acquired candidemia in mechanically ventilated ICU patients: a multicenter nationwide study

 

All patients

n = 5862

Standard care

n = 2931

SDD

n = 2931

p value

Ouctomes

    

Candidemia

31 (0.5)

23 (0.8)

8 (0.3)

0.012

Sources of candidemiaa

   

0.65

Catheter

9 (29.0)

7 (30.4)

2 (25.0)

 

Digestive

6 (19.3)

5 (21.7)

1 (12.5)

 

Other or unknown

14 (45.2)

10 (43.5)

4 (50.0)

 

Pleuro-pulmonary site

1 (3.2)

1 (4.3)

0 (0.0)

 

Skin

1 (3.2)

0 (0.0)

1 (12.5)

 

Candida species isolated

   

0.186

Candida albicans

21 (67.7)

16 (69.6)

5 (62.5)

 

Candida glabrata

3 (9.7)

3 (13.0)

0 (0.0)

 

Candida parapsilosis

1 (3.2)

1 (4.3)

0 (0.0)

 

Candida tropicalis

2 (6.4)

2 (8.7)

0 (0.0)

 

Candida krusei

2 (6.4)

1 (4.3)

1 (12.5)

 

Other Candida species

2 (6.4)

0 (0.0)

2 (25.0)

 

MDR bacteria acquisitionb

103 (2.9)

82 (4.6)

21 (1.2)

<0.001

ICU length of stay (days)

9 [5–18]

9 [5–18]

9 [5–17]

0.513

Duration of mechanical ventilation (days)

6 [3–12]

6 [3–12]

6 [3–21]

0.120

ICU case fatality

1821 (31.1)

908 (31.0)

913 (31.1)

0.910

  1. Data are presented as median (IQR: interquartiles), n (%)
  2. ICU intensive care unit, SDD: selective digestive decontamination, MDR multidrug resistant
  3. aSource of candidemia was assessed when colonization with the same Candida Spp was identified as causative pathogen
  4. bMissing data: n = 2364