Skip to main content

Table 2 Diagnostic performance of tests used alone and combined considering the Candida culture of peritoneal samples

From: Combination of serum and peritoneal 1.3-beta-d-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study

Test

Number of patients above the threshold

Sensitivity

Specificity

Positive predictive value

Negative predictive value

Peritonitis score ≥ 3

106/199

62.1 [51.6–71.5]

53.6 [44.4–62.5]

50.9 [41.6–60.3]

64.5 [54.4–73.5]

Serum BDG (FA) ≥ 80 pg/ml

65/140

59.0 [46.5–70.5]

63.3 [52.3–73.1]

55.4 [43.3–66.8]

66.7 [55.4–76.3]

Serum BDG (WT) ≥ 3.3 pg/ml

18/42

70.6 [46.9–86.7]

76.0 [56.6–88.5]

66.7 [43.7–83.7]

79.2 [59.5–90.8]

Peritoneal BDG (WT) ≥ 45 pg/ml

145/196

89.5 [81.3–94.4]

38.2 [29.6–47.5]

53.1 [45.0–61.0]

82.3 [69.7–90.4]

Peritoneal BDG (WT) ≥ 45 pg/ml or serum BDG (FA) ≥ 80 pg/ml or peritonitis score ≥ 3

130/140

98.5 [92.2–99.7]

11.1 [5.1–18.3]

48.6 [40.4–56.8]

90.0 [59.6–98.2]

Peritoneal BDG (WT) ≥ 45 pg/ml or serum BDG (WT) ≥ 3.3 pg/ml or peritonitis score ≥ 3

35/42

100.0

28.0 [14.3–47.6]

48.6 [33.0–64.4]

100.0

  1. Results expressed as % [95% confidence interval]. The results of serum BDG that were considered was Day 1. Serum BDG with FA test: n = 140 (61 IAC+ /79 IAC−) with WT: n = 42 (17 IAC+ /25 IAC−).
  2. BDG: 1.3 beta-d-glucan; FA: Fungitell® beta-d-glucan assay (Associate of Cape Cod, East Falmouth, Inc., United States of America); WT: Wako® beta-glucan test (Fujifilm Wako Chemicals Europe, Neuss, Germany)