Research topic | The first guideline citating the sRCT | Recommendation in the first guideline citing the sRCT | Guideline removing or suggesting against the sRCT | Current recommendation in guidelines |
---|---|---|---|---|
16 sRCTs with subsequent mRCTs | ||||
Anti-lipopolysaccharide immunotherapy in sepsis, 1984 [14] | Not available | Not applicable | Not applicable | Not applicable |
Terlipressin for upper gastrointestinal bleeding in cirrhotic patients, 1995 [15] | 2018 [50] | Suggested | Not applicable | Suggested [50] |
Non-invasive ventilation in immunosuppressed patients, 2000 [7] | 2015 [51] | Some evidence of benefit in certain patients with immunosuppression | 2020 [52] | Suggested [52] |
High-volume ultrafiltration in acute renal failure, 2000 [20] | 2008 [53] | Insufficient evidence | 2021 [54] | Insufficient evidence [54] |
Non-invasive ventilation in immunosuppressed patients, 2001 [13] | 2015 [51] | Some evidence of benefit in certain patients with immunosuppression | 2023 [55] | Suggested [55] |
Early goal-directed therapy in sepsis, 2001 [19] | 2004 [56] | Recommended | 2017 [57] | Not mentioned [54] |
Intensive insulin therapy, 2001 [23] | 2004 [56] | Recommended with a glucose goal of < 150 mg/dL | 2013 [58] | Suggested against [54] |
Amiodarone in refractory ventricular fibrillation, 2002 [11] | 2006 [59] | Recommended | 2019 [60] | Suggested [61] |
Daily hemodialysis in acute renal failure, 2002 [22] | 2008 [53] | Insufficient evidence | 2013 [58] | Not mentioned [54] |
Selective decontamination of digestive tract, 2003 [9] | 2008 [53] | No recommendation | 2016 [57] | Not mentioned [54] |
Charcoal in poisoning, 2003 [10] | Not available | Not applicable | Not applicable | Not applicable |
Epinephrine during cardiopulmonary resuscitation, 2009 [17] | 2010 [62] | Insufficient evidence | 2015 [63] | Recommended [64] |
Beta blocker in sepsis, 2013 [16] | Not available | Not applicable | Not applicable | Not applicable |
Restrictive transfusion threshold in upper gastrointestinal bleeding, 2013 [24] | 2016 [65] | Recommended | Still cited in the current guideline [66] | Suggested [66] |
Oxygen targets, 2016 [12] | 2021 [54] | Insufficient evidence | Not available | Insufficient evidence [54] |
Early initiation of renal replacement therapy in acute kidney injury, 2016 [25] | 2021 [54] | Suggested against | Not available | Suggested against [54] |
3 sRCTs without subsequent mRCTs | ||||
Interpose abdominal counterpulsation during cardiac arrest, 1992 [21] | 2005 [67] | No clear statement | 2015 [63] | Not mentioned [64] |
Supranormal oxygen delivery, 1993 [8] | Not available | Not applicable | Not available | Not applicable |
Hemofiltration vs peritoneal dialysis in acute renal failure, 2002 [18] | Not available | Not applicable | Not applicable | Not applicable |