Table 2 Subsequent multicenter randomized trials and their mortality findings
sRCT | References of mRCT | Number of patients | Number of centers | Number of countries | Mortality |
|---|---|---|---|---|---|
Anti-lipopolysaccharide immunotherapy in sepsis, 1984 [14] | Greenman et al. [37] | 486 | 33 | 1 | No statistically significant difference |
Angus et al. [26] | 1102 | 136 | 1 | No statistically significant difference | |
Interpose abdominal counterpulsation during cardiac arrest, 1992 [21] | Not available | Â | Â | Â | Â |
Supranormal oxygen delivery, 1993 [8] | Not available | Â | Â | Â | Â |
Terlipressin for upper gastrointestinal bleeding in cirrhotic patients, 1995 [15] | Feu et al. [33] | 161 | 4 | 1 | No statistically significant difference |
Escorsell et al. [32] | 219 | 9 | 2 | No statistically significant difference | |
Non-invasive ventilation in immunosuppressed patients, 2000 [7, 13] | Lemiale et al. [41] | 374 | 28 | 2 | No statistically significant difference |
High-intensity renal replacement therapy in acute renal failure, 2000 [20] | Palevsky et al. [44] | 1124 | 27 | 1 | No statistically significant difference |
Bellomo et al. [29] | 1508 | 35 | 2 | No statistically significant difference | |
Early goal-directed therapy in sepsis, 2001 [19] | Peake et al. [45] | 1600 | 51 | 5 | No statistically significant difference |
Yealy et al. [49] | 1341 | 31 | 1 | No statistically significant difference | |
Mouncey et al. [42] | 1260 | 56 | 1 | No statistically significant difference | |
Intensive insulin therapy, 2001 [23] | Finfer et al. [34] | 6104 | 42 | 4 | Statistically significant mortality increase at 90Â days (28% vs. 25%) |
Amiodarone in refractory ventricular fibrillation, 2002 [11] | Kudenchuk et al. [40] | 3026 | 10a | 2 | No statistically significant difference |
Daily hemodialysis in acute renal failure, 2002 [22] | Ponce et al. [47] | 407 | 2 | 1 | No statistically significant difference |
Hemofiltration versus peritoneal dialysis in acute renal failure, 2002 [18] | Not available | Â | Â | Â | Â |
Selective decontamination of digestive tract, 2003 [9] | de Smet et al. [30] | 5939 | 13 | 1 | No statistically significant difference |
Myburgh et al. [43] | 5982 | 19 | 1 | No statistically significant difference | |
Charcoal in poisoning, 2003 [10] | Eddleston et al. [31] | 4632 | 3 | 1 | No statistically significant difference |
Epinephrine during cardiopulmonary resuscitation, 2009 [17] | Perkins et al. [46] | 8014 | 5b | 1 | Statistically significant mortality reduction at 30Â days (3.2% vs 2.4%) |
Beta blocker in sepsis, 2013 [16] | Kakihana et al. [39] | 151 | 54 | 1 | No statistically significant difference |
Transfusion thresholds in upper gastrointestinal bleeding, 2013 [24] | Jairath et al. [38] | 936 | 6 | 1 | No statistically significant difference |
Oxygen targets, 2016 [12] | Schjørring et al. [48] | 2928 | 35 | 7 | No statistically significant difference |
Gelissen et al. [36] | 574 | 4 | 1 | No statistically significant difference | |
Timing of renal replacement therapy in acute kidney injury, 2016 [25] | Gaudry et al. [35] | 620 | 31 | 1 | No statistically significant difference |
Barbar et al. [28] | 488 | 29 | 1 | No statistically significant difference | |
Bagshaw et al. [27] | 3019 | 168 | 15 | No statistically significant difference |