Table 1 Single-center randomized trials with statistically significant survival benefits
References | Number of patients | Population | Intervention | Control | Mortality timepoint |
|---|---|---|---|---|---|
Lachman et al. [14] | 33 | Septic shock | Anti-lipopolysaccharide immunoglobulin G | Conventional treatment | 7.1% versus 47% Hospital discharge |
Sack et al. [21] | 103 | In-hospital cardiac arrest | Interposed abdominal counterpulsation | Standard care | 75% versus 93% Hospital discharge |
Boyd et al. [8] | 107 | High-risk surgical patients | Supranormal oxygen delivery | Conventional therapy | 5.7% versus 22% 28Â days |
Levacher et al. [15] | 76 | Upper gastrointestinal bleeding | Terlipressin plus glyceryl trinitrate | Placebo | 20% versus 42% 15Â days |
Antonelli et al. [7] | 40 | Acute respiratory failure after solid organ transplantation | Non-invasive ventilation | Supplemental oxygen | 20% versus 50% ICU discharge |
Ronco et al. [20] | 425 | Acute renal failure in ICU | Higher intensity renal replacement therapy | Low or intermediate volume ultrafiltration | 41% versus 57% versus 58% 15Â days |
Rivers et al. [19] | 263 | Sepsis and septic shock | Early goal-directed therapy | Standard care | 44% versus 57% 60Â days |
Hilbert et al. [13] | 52 | Acute respiratory failure in immunosuppressed patients | Non-invasive ventilation | Supplemental oxygen | 50% versus 81% Hospital discharge |
van der Berghe et al. [23] | 1548 | ICU patients | Intensive insulin therapy | Conventional therapy | 4.6% versus 8.0% Hospital discharge |
Dorian et al. [11] | 347 | Out-of-hospital ventricular fibrillation | Amiodarone | Lidocaine | 77% versus 88% Hospital discharge |
Schiffl et al. [22] | 160 | Acute renal failure | Daily intermittent hemodialysis | Alternate-day hemodialysis | 28% versus 46% 14Â days |
Phu et al. [18] | 70 | Acute renal failure with urgent renal replacement therapy indication | Venovenous dialysis | Peritoneal dialysis | 15% versus 47% Hospital discharge |
de Jonge et al. [9] | 934 | Patients on mechanical ventilation | Selective decontamination digestive tract | Standard care | 24% versus 31% Hospital discharge |
de Silva et al. [10] | 401 | Yellow-oleander poisoning | Charcoal | Placebo | 2.5% versus 8.0% Hospital discharge |
Olasveengen et al. [17] | 1183 | Out-of-hospital nontraumatic cardiac arrest | CPR with epinephrine administration | CPR without epinephrine administration | 68% versus 79% Hospital admission |
Morelli et al. [16] | 154 | Septic shock | Esmolol infusion | Standard care | 49% versus 81% 28Â days |
Villanueva et al. [24] | 921 | Upper gastrointestinal bleeding | Restrictive transfusion strategy | Liberal transfusion strategy | 5.0% versus 8.9% 45Â days |
Girardis et al. [12] | 434 | ICU patients | Conservative oxygen supplementation | Conventional oxygen supplementation | 12% versus 20% ICU discharge |
Zarbock et al. [25] | 231 | Acute kidney injury stage 2 | Early renal replacement therapy | Delayed renal replacement therapy | 39% versus 55% 90Â days |