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Table 3 Associations of patient and clinical characteristics with sustained RTW

From: Return to work after hospitalization for sepsis: a nationwide, registry-based cohort study

Variable

Person year (py) at risk

Events

Rate per py

Crude HR

Adjusteda HR (95% C)

Age-group

     

 18–29

720

1 779

2.47

1.00

1.00 (Reference)

 30–39

824

1 966

2.38

0.90

0.90 (0.84 − 0.96)

 40–49

1 080

2 552

2.36

0.80

0.78 (0.75 − 0.85)

 50–60

1 595

3 592

2.25

0.69

0.69 (0.65 − 0.73)

Sex

     

 Male

2 579

5 939

2.30

1.00

1.00 (Reference)

 Female

1 639

3 950

2.41

1.03

1.01 (0.97 − 1.05)

ICU treatmentb

     

 No

2 335

5 974

2.56

1.00

1.00 (Reference)

 Yes

396

660

1.67

0.57

0.56 (0.52 − 0.61)

Sepsis subgroupc

     

 Sepsis

362

989

2.73

1.00

1.00 (Reference)

 COVID-19-related

95

324

3.41

1.25

1.31 (1.15 − 1.49)

Site of infectiond

     

 Respiratory

988

2 462

2.49

1.00

1.00 (Reference)

 Genitourinary

260

785

3.01

1.40

1.38 (1.27 − 1.50)

 Intra-abdominal

162

391

2.41

1.03

1.03 (0.92 − 1.14)

 Gastrointestinal infections

169

637

3.80

1.69

1.64 (1.51 − 1.79)

 Skin and soft tissue

105

276

2.64

1.26

1.27 (1.12 − 1.44)

 Infections following a procedure

136

244

1.80

0.83

0.84 (0.73 − 0.96)

 Endocarditis/myocarditis

46

74

1.60

0.70

0.70 (0.56 − 0.88)

 Other infectionse

793

1 800

2.27

1.00

0.96 (0.91 − 1.02)

Comorbiditiesd

     

 Heart and vascular

652

1 175

1.80

1.00

1.00 (Reference)

 Cancer

749

736

0.98

0.52

0.52 (0.48 − 0.58)

 Lung

139

367

2.65

1.57

1.60 (1.42 − 1.80)

 Diabetes

97

269

2.80

1.58

1.58 (1.39 − 1.81)

 Renal

17

25

1.48

0.99

0.98 (0.66 − 1.46)

 Immune

29

99

3.42

2.07

2.06 (1.67 − 2.53)

 Liver

5

10

2.03

0.60

0.62 (0.33 − 1.15)

No. of comorbidities

     

 0

2 113

6 598

3.12

1.00

1.00 (Reference)

 1

1 687

2 681

1.59

0.45

0.46 (0.44 − 0.48)

 2

377

547

1.45

0.38

0.39 (0.36 − 0.42)

  ≥ 3

41

63

1.55

0.30

0.32 (0.25 − 0.41)

Type of acute organ dysfunctiond

     

 Respiratory

819

1 858

2.27

1.00

1.00 (Reference)

 Renal

563

1 761

3.12

1.45

1.48 (1.39 − 1.58)

 Circulatory

187

353

1.89

0.89

0.91 (0.82 − 1.03)

 Coagulation

332

407

1.23

0.62

0.64 (0.58 − 0.71)

 Hepatic

37

66

1.79

0.83

0.82 (0.64 − 1.04)

 Other acute organ dysfunctionsf

275

735

2.67

1.33

1.30 (1.19 − 1.41)

No. of acute organ dysfunctions

     

 1

2 214

5 180

2.34

1.00

1.00 (Reference)

 2

337

492

1.46

0.60

0.60 (0.55 − 0.66)

 3

82

109

1.33

0.57

0.56 (0.46 − 0.68)

  ≥ 4

18

25

1.42

0.49

0.49 (0.33 − 0.72)

  1. Abbrevation: HR =hazard ratio, CI = confidence interval, ICU = intensive care unit,
  2. aCox regression with time to death as dependent variable, the listed variable as covariate (one at the time), and sex and age
  3. bEnter date = May 1, 2014
  4. cEnter date = February 28, 2020
  5. dCategorical variable where one ICD-10 code excludes other ICD-10 codes in the same diagnosis group
  6. eOther infections = Bone, obstetric, upper airway, central nervous system and unknown
  7. fOther acute organ dysfunctions = Acidosis, unspecific gangrene, central nervous system dysfunctions and Systemic Inflammatory Response Syndrome