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Fig. 1 | Critical Care

Fig. 1

From: Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest

Fig. 1

Example of a dose–response hazard ratio plot based on the open access Mayo Clinic Primary Biliary Cholangitis Dataset. A multivariable Cox proportional hazards model was fitted, conditioning on treatment received and bilirubin level. To relax the linearity assumption, restricted cubic splines with four knots were fitted for age and bilirubin. Note the selected reference point where the 95% CI collapses. The R code for creating this figure can be found online (https://gitlab.com/tobiaszimmermann/ltte_critcare_grand_2023)

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