Fig. 3

Temporal changes in C-reactive protein and procalcitonin plasma concentrations. A Mean fold change from baseline CRP levels in all patients with an available value was calculated per patient. The mean ± SD baseline for the trimodulin group was 222 ± 129 mg/L and 227 ± 147 mg/L for the placebo group. The dotted line (0) represents the no-change level. Patient numbers decreased after Day 2 due to discharge or death (indicated at the top of the figure). Repeated measures ANOVA assessed between-subject effects of treatment over time (from baseline to Day 7). *Indicates p < 0.05 (t-test with Welch’s correction: Day 3, p = 0.0281; Day 4, p = 0.0291). B PCT (mean + SD) in the subgroup of patients with baseline PCT ≤ 10 µg/L (n = 92). A significant difference between overall PCT concentration-time profiles was found between groups, but no statistically significant differences were observed at single timepoints. ANOVA analysis of variance, BL baseline, CRP C-reactive protein, PCT procalcitonin, SD standard deviation