Fig. 2
Cellular pharmacodynamic responses in sCAP patients modulated by trimodulin. A Time course of ALC in all patients (ALCAll) during (Day 1–5) and after treatment (Day 6–7) with trimodulin or placebo. The numbers of subjects per group and per day are indicated above the graph. The dotted line represents the threshold for normal ALC (≥ 1.0 × 109/L). B As in A, for the subgroup of patients who also had low baseline IgM (≤ 0.8 g/L) (ALCALL IgMlow [trimodulin, median IgM 0.46 g/L and median ALC 0.64 × 109/L; placebo, median IgM 0.44 g/L and median ALC 0.68 × 109/L). C Bar graph showing the percentage of patients at different timepoints with normal ALC. D Time course of neutrophil levels in all patients treated with trimodulin or placebo. The dotted line represents the threshold for neutrophilia (≥ 8.0 × 109/L, ANChigh). E Time course of neutrophil levels in the subgroup of patients in the ANChigh subgroup during and after treatment with trimodulin or placebo. F As in E for the ANCnormal IgMlow subgroup of patients with low IgM. G Bar graph showing the proportion of patients in the ANCnormal IgMlow subgroup where ANC remains normal over time. H Time course of the NLR in patients treated with trimodulin or placebo. Dotted lines: NLR values between 9 and 18 reflect moderate illness, whereas higher values reflect severe/critical disease and lower values mild illness [38]. I NLR as in H for the IgMlow subgroup of patients. J NLR as in H for the ANChigh subgroup. K Bar graph showing the proportion of patients in the NLRhigh IgMlow subgroup returning to NLR levels < 9 during and after treatment with trimodulin or placebo. To analyze statistical differences in the overall course of responses ANOVA was used in (A–B, D–F). On each treatment day the two-tailed Chi-square test was used to assess the statistical significance of differences between the two treatment groups in the % of patients with lymphocytes returning to ≥ 1.0 × 109/L (C), neutrophils remaining at < 8.0 × 109/L (G) or an NLR returning to < 9 (K). For days where differences were statistically significant, p-values are given above the bars. For further details see Additional file 1: Fig. S5. ALC absolute lymphocyte count, ANC absolute neutrophil count, ANOVA analysis of variance, BL baseline, Ig immunoglobulin, NLR neutrophil-to-lymphocyte ratio