Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis

Table 4 Immunophenotyping of sepsis patients by HCMV serostatus. P-values of p < 0.002 were considered significant as determined by Bonferroni correction

	HCMV seronegative	HCMV seropositive	p-value
n	54	91
Leucocytes median [IQR]	14,159 [13508]	11,805 [9073]	0.245
Granulocytes median [IQR]	11,883 [12389]	9616 [8824]	0.273
Lymphocytes median [IQR]	738 [846]	646 [738]	0.167
CD3⁻ CD56⁻ cells median [IQR]	193 [260]	142 [178]	0.072
B-cells median [IQR]	106 [174]	63 [108]	0.065
NK cells median [IQR]	97 [87]	59 [79]	0.012
CD56^bright cells median [IQR]	4 [5]	3 [8]	0.984
CD56^dim cells median [IQR]	81 [81]	45 [82]	0.007
NKT cells median [IQR]	7 [11]	22 [45]	< 0.001
T-cells median [IQR]	499 [523]	365 [441]	0.275
CD4⁺ T-cells median [IQR]	364 [411]	218 [330]	0.032
CD4⁺ CM median [IQR]	101 [115]	59 [83]	0.034
CD4⁺ EM median [IQR]	78 [109]	59 [92]	0.237
CD4⁺ naïve median [IQR]	138 [208]	78 [161]	0.034
CD4⁺ TEMRA median [IQR]	8 [21]	8 [21]	0.894
CD4⁻ CD8⁻ T-cells median [IQR]	14 [21]	11 [16]	0.132
CD8⁺ T-cells median [IQR]	84 [123]	106 [165]	0.062
CD8⁺ CM median [IQR]	21 [35]	24 [44]	0.314
CD8⁺ EM median [IQR]	19 [26]	16 [35]	0.289
CD8⁺ naïve median [IQR]	27 [57]	39 [71]	0.095
CD8⁺ TEMRA median [IQR]	11 [28]	34 [89]	< 0.001
CD14⁺ monocytes median [IQR]	1586 [2651]	1051 [2362]	0.072
classical monocytes median [IQR]	1375 [2328]	872 [2233]	0.067
intermediate monocytes median [IQR]	24 [48]	16 [43]	0.479
non-classical monocytes median [IQR]	8 [21]	4 [8]	0.031

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