Table 3 Cytokine concentrations (pg/mL) in the sera from seropositive and seronegative patients at study inclusion
From: Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
| Â | Entire cohort | HCMV-seronegative | HCMV-seropositive | p-value |
|---|---|---|---|---|
n | 334 | 117 | 217 | Â |
IL-1B median [IQR] | 5.1 [2.7–8.9] | 5.1 [1.1–9.0] | 5.1 [2.7–8.9] | 0.649 |
IFN-α median [IQR] | 1.6 [1.2–2.7] | 1.6 [1.1–2.4] | 1.6 [1.2–2.9] | 0.679 |
IFN-γ median [IQR] | 4.0 [0.0–10.2] | 4.9 [0.3–10.2] | 4.0 [0.0–10.2] | 0.647 |
TNF-α median [IQR] | 5.9 [0.0–10.9] | 5.3 [0.0–9.3] | 6.3 [0.0–11.3] | 0.066 |
MCP-1 median [IQR] | 272.9 [147.5–528.7] | 248.5 [143.9–466.7] | 306.0 [150.4–570.5] | 0.242 |
IL-6 median [IQR] | 215.1 [67.4–593.2] | 170.1 [71.1–481.2] | 259.9 [64.4–654.7] | 0.330 |
IL-8 median [IQR] | 77.9 [31.8–186.2] | 61.0 [26.9–121.8] | 84.2 [37.0–199.6] | 0.004 |
IL-10 median [IQR] | 7.6 [2.3–23.9] | 6.7 [2.2–17.7] | 8.2 [2.3–25.6] | 0.183 |
IL-12 median [IQR] | 2.8 [0.0–4.4] | 2.9 [0.0–4.4] | 2.8 [1.5–4.4] | 0.693 |
IL17 median [IQR] | 0.5 [0.3–0.9] | 0.5 [0.3–0.8] | 0.5 [0.3–0.9] | 0.177 |
IL-18 median [IQR] | 287.0 [138.6–699.3] | 225.8 [115.7–548.2] | 345.1 [153.3–771.4] | 0.009 |
IL-23 median [IQR] | 6.5 [0.0–27.5] | 10.7 [0.0–30.3] | 6.1 [0.0–25.4] | 0.145 |
IL-33 median [IQR] | 23.0 [9.7–46.5] | 25.6 [12.0–47.5] | 22.5 [9.7–46.5] | 0.743 |