Table 2 Basic characteristics of the cohort divided into the HCMV-seronegative and seropositive groups
From: Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
| Â | Entire cohort | HCMV-seronegative | HCMV-seropositive | p-value | n |
|---|---|---|---|---|---|
n | 410 | 151 | 259 | Â | 410 |
Male gender n (%) | 250 (61%) | 104 (72%) | 146 (60%) | 0.022 | 388 |
Age years median [IQR] | 67 [57–77] | 63 [54–74] | 68 [59–78] | 0.004 | 398 |
SOFA score median [IQR] | 9 [6–12] | 8 [5–11] | 9 [6–12] | 0.008 | 390 |
SAPS-2 DRG median [IQR] | 38 [29–48] | 34 [26–47] | 40 [30–48] | 0.019 | 319 |
PCT ng/mL median [IQR] | 3.0 [0.6–12.3] | 3.0 [0.5–13.0] | 3.0 [0.7–12.2] | 0.700 | 317 |
CRP mg/dL median [IQR] | 15 [9–26] | 14 [9–26] | 16 [9–27] | 0.371 | 299 |
Lactat mM median [IQR] | 1.7 [1.2–3.2] | 1.6 [1.1–2.9] | 1.8 [1.2–3.3] | 0.077 | 330 |
Comorbidities n (%) | 340 | 124 | 176 | Â | 340 |
 Alcohol | 27 (8) | 10 (8) | 17 (8) | 1.000 |  |
 Chronic kidney disease | 85 (25) | 28 (23) | 57 (26) | 0.516 |  |
 Hypertension | 214 (63) | 74 (60) | 216 (65) | 0.044 |  |
 Diabetes | 87 (26) | 25(20) | 62 (29) | 0.094 |  |
 Obesity | 83 (24) | 28 (23) | 55 (25) | 0.601 |  |
 Cardiovascular | 100 (29) | 30 (24) | 70 (32) | 0.138 |  |
 Malignancies | 105 (31) | 42 (34) | 63 (29) | 0.394 |  |
 Nicotine | 90 (26) | 34 (27) | 56 (26) | 0.799 |  |
 Dialysis | 37 (11) | 10 (8) | 27 (13) | 0.278 |  |
 Transplantation | 53 (16) | 12 (10) | 41 (19) | 0.029 |  |
 COPD | 38 (11) | 15 (12) | 23 (11) | 0.722 |  |
 Other (lungs) | 24 (7) | 11 (9) | 13 (6) | 0.380 |  |
Focus of infection n (%) | 362 | 135 | 227 | Â | 362 |
 Central nervous system | 9 (3) | 6 (3) | 3 (1) | 0.065 |  |
 Lower respiratory tract | 161 (45) | 64 (47) | 97 (43) | 0.387 |  |
 Genitourinary | 25 (7) | 11 (8) | 14 (6) | 0.472 |  |
 Intra-abdominal | 106 (29) | 35 (26) | 71 (31) | 0.279 |  |
other | 61 (17) | 19 (14) | 42 (19) | 0.276 | Â |
Leukocytes 103/median [IQR] | 14 [9–19] | 15 [10–19] | 13 [8–20] | 0.432 | 219 |
Surgical patient n (%) | 293 (78) | 105 (76) | 188 (79) | 0.444 | 377 |
ICU length of stay median days [IQR] | 7 [3–15] | 7 [3–15] | 7 [3–15] | 0.557 | 345 |
Hospital length of stay median days [IQR] | 18 [10–34] | 24 [11–41] | 16 [9–29] | 0.008 | 317 |
30-day mortality n (%) | 136 (33) | 37 (25%) | 99 (38%) | 0.005 | 410 |