Epidemiology of ischemic stroke and hemorrhagic stroke in venoarterial extracorporeal membrane oxygenation

Table 2 Logistic regression of risk factors for ischemic or hemorrhagic stroke incidence^{^}

	Odds ratio	95% CI	p value
Ischemic stroke incidence
Age (years)	1.006	0.998–1.013	0.18
Center volume per year	1.005	0.998–1.012	0.17
Year of ECMO support
2019^a	0.990	0.707–1.390	0.95
2020^a	1.042	0.741–1.467	0.81
2021^a	1.113	0.795–1.564	0.53
Aortic cannulation	0.887	0.645–1.199	0.45
ABG related factors
24-h PaO₂ (mmHg)	1.002	1.001–1.002	0.0006
ΔPaCO₂ (mmHg)	0.990	0.984–0.996	0.0009
24-h Blood Pump Flow Rate (L/minute)	1.071	0.941–1.219	0.30
Hemorrhagic Stroke Incidence
Age (years)	0.998	0.987–1.010	0.80
Center volume per year	1.009	0.998–1.019	0.09
Year of ECMO Support
2019^a	1.385	0.828–2.366	0.22
2020^a	1.304	0.766–2.257	0.33
2021^a	1.384	0.816–2.389	0.23
Aortic cannulation	0.825	0.485–1.329	0.45
ABG related factors
24-h PaO₂ (mmHg)	0.999	0.997–1.000	0.21
ΔPaCO₂ (mmHg)	1.000	0.990–1.011	0.98
24-h blood pump flow rate (L/minute)	0.986	0.812–1.197	0.89

Bolded text: Statistically significant with p < 0.05
Abbreviations: ^:12,327 patients from 2018 to 2021 with complete mortality data; ^aYear 2018 was used as the dummy variable, as the year of ECMO support was used as a categorical variable; ΔPaCO₂: change in arterial carbon dioxide pressure between pre-ECMO and 24-h post-cannulation; 24-h PaO₂: 24-h post-cannulation arterial oxygen pressure; ABG: arterial blood gas; CI: confidence interval; ECMO: extracorporeal membrane oxygenation

ISSN: 1364-8535