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Table 2 Hazard ratios for association of cardiac index and mixed venous oxygen saturation upon insertion of pulmonary artery catheter (T0) and death from all causes at 356 days

From: Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest

 

Hazard ratios for death

 

Cardiac Index (n = 565)

Mixed Venous Oxygen Saturation (n = 542)

 

Univariable HR (95% CL)

p-value

Multivariable* HR (95% CL)

p-value

Univariable HR (95% CL)

p-value

Multivariable* HR (95% CL)

p-value

Cardiac index/quartile 1, n = 142

1.58 (1.07–2.33)

0.02

1.35 (0.91–2.01)

0.14

    

Cardiac index/quartile 2, n = 141, reference

-

-

-

-

    

Cardiac index/quartile 3, n = 141

1.06 (0.69–1.62)

0.78

0.93 (0.61–1.44)

0.75

    

Cardiac index/quartile 4, n = 141

1.00 (0.65–1.55)

0.99

0.78 (0.49–1.12)

0.28

    

Mixed Venous Oxygen Saturation/5%

    

0.89 (0.83–0.96)

0.001

0.91 (0.84–0.98)

0.01

Age at arrest/5 year

1.19 (1.12–1.28)

 < 0.0001

1.19 (1.11–1.29)

 < 0.0001

  

1.19 (1.11–1.28)

 < 0.0001

Sex, female

1.03 (0.69–1.52)

0.89

1.23 (0.86–1.75)

0.26

  

1.23 (0.86–1.75)

0.26

BMI

1.03 (1.01–1.06)

0.02

1.02 (0.99–1.06)

0.31

  

1.03 (0.99–1.06)

0.10

Allocated to MAP 77 mmHg

1.12 (0.83–1.50)

0.44

1.18 (0.88–1.58)

0.25

  

1.12 (0.84–1.49)

0.43

Allocated to liberal PaO2-target

1.12 (0.83–1.51)

0.46

1.03 (0.76–1.37)

0.86

  

1.05 (0.79–1.41)

0.70

Time to ROSC/min

1.03 (1.03–1.04)

 < 0.0001

1.03 (1.03–1.04)

 < 0.0001

  

1.03 (1.02–1.04)

 < 0.0001

Shockable primary rhythm

0.58 (0.40–0.82)

0.003

0.59 (0.42–0.85)

0.0034

  

0.60 (0.42–0.87)

0.0075

STEMI

0.95 (0.70–1.29)

0.75

1.04 (0.77–1.40)

0.78

  

1.06 (0.79–1.42)

0.69

LVEF upon admission

0.99 (0.98–0.99)

0.01

1.01 (0.99–1.01)

0.80

  

1.00 (0.99–1.01)

0.93

Hypertension

1.43 (1.06–1.93)

0.02

1.12 (0.81–1.52)

0.61

  

1.11 (0.81–1.52)

0.44

  1. CL Confidence limit, BMI body mass index, MAP mean arterial blood pressure, PaO2 arterial partial pressure of oxygen, CPR cardiopulmonary resuscitation, STEMI ST-elevation myocardial infarction, HR hazard ratio, ROSC return of spontaneous circulation. Bold indicates statistical significance which is a p-value below 0.05