Fluid balance control in critically ill patients: results from as-treated analyses of POINCARE-2 randomized trial

Table 3 Effect of the exposure to the POINCARE-2 strategy on vital status at Day60

	Complete cases^a			Multiple imputation^b
	OR (Score > 75%)	95% CI	p	OR (Score > 75%)	95% CI	p
Unadjusted^c	1.43	1.04–1.98	0.029	1.47	1.12–1.93	0.005
Adjusted for measured confounders^d	1.12	0.78–1.60	0.547	1.15	0.85–1.55	0.356
Adjusted for measured and unmeasured confounders^e	0.97	0.70–1.34	0.843	1.01	0.76–1.33	0.956

Models:
^cAdjusted only on class variables: Center and Secular time
^dadjusted on Center, Secular time, Age (years), Heart failure, Chronic kidney disease under RRT, McCabe Score at admission, SAPS II (*), Main cause of admission, SOFA ( ~), RRT (#) at day 0
^e2SRI instrumental variable model adjusted on Center, Secular time, Age (years), Cirrhosis, Cancer, Immunodeficiency, Heart failure, Chronic respiratory failure, Chronic kidney disease under RRT, McCabe Score at admission, SAPS II (*), Main cause of admission, BMI (IOTF classification), Weight (kg), Serum bicarbonate (mmol/L), Serum potassium (mmol/L), SOFA ( ~), Serum creatinine (mg/dL), PaO²/FiO² (mmHg), RRT (#) at day 0
Analyses:
^aObservations with missing data are excluded (n = 977)
^bNumber of imputation datasets = 4 (n = 1361)
*SAPS: Simplified Acute Physiology Score
~ SOFA: Sequential Organ Failure Assessment
^#RRT: Renal-replacement therapy

ISSN: 1364-8535