Table 2 Occurrence of primary and secondary outcomes
Score of exposure to the strategy | Total N = 1361 | |||||
|---|---|---|---|---|---|---|
[0;25[ | [25;50[ | [50;75[ | [75;100] | |||
N = 74 | N = 288 | N = 375 | N = 624 | |||
Primary outcome | ||||||
Vital status at day 60 | ||||||
Lost of follow-up | 0 | 1 | 4 | 2 | 7 | |
Alive | 45 (60.8%) | 204 (70.8%) | 258 (68.8%) | 407 (65.2%) | 914 (67.2%) | |
Deceased | 29 (39.2%) | 83 (28.8%) | 113 (30.1%) | 215 (34.5%) | 440 (32.3%) | |
Survival time (days)—truncated at Day 60 | ||||||
N | 74 | 288 | 375 | 624 | 1361 | |
Mean (std) | 43.5 (22.28) | 48.3 (19.85) | 47.0 (20.82) | 46.2 (20.36) | 46.7 (20.50) | |
Min–median–max | 3–60.0–60 | 4–60.0–60 | 3–60.0–60 | 2–60.0–60 | 2–60.0–60 | |
Secondary outcomes | ||||||
Effectiveness | ||||||
Number of days without mechanical ventilation during Day0 – Day28 | ||||||
N | 74 | 288 | 375 | 624 | 1361 | |
Mean (std) | 8.4 (8.90) | 10.2 (8.26) | 9.9 (8.61) | 9.4 (8.54) | 9.7 (8.52) | |
Min–median–max | 0–5.0–26 | 0–10.0–26 | 0–9.0–28 | 0–8.0–27 | 0–9.0–28 | |
Number of days without vasopressor during Day0 – Day28 | ||||||
N | 74 | 288 | 375 | 624 | 1361 | |
Mean (std) | 15.0 (10.07) | 17.0 (9.59) | 14.8 (9.48) | 15.1 (9.46) | 15.4 (9.55) | |
Min–median–max | 0–14.5–28 | 0–20.0–28 | 0–14.0–28 | 0–16.0–28 | 0–16.0–28 | |
Number of days without RRT (#) during Day0 – Day60 | ||||||
N | 74 | 288 | 375 | 624 | 1361 | |
Mean (std) | 27.3 (20.50) | 30.0 (19.90) | 26.7 (19.57) | 27.2 (20.31) | 27.7 (20.05) | |
Min–median–max | 0–21.5–60 | 0–27.0–60 | 0–21.0–60 | 0–21.5–60 | 0–22.0–60 | |
Vital status at Day 28 | ||||||
Missing | 0 | 0 | 1 | 2 | 3 | |
Alive | 51 (68.9%) | 225 (78.1%) | 279 (74.4%) | 458 (73.4%) | 1013 (74.4%) | |
Deceased | 23 (31.1%) | 63 (21.9%) | 95 (25.3%) | 164 (26.3%) | 345 (25.3%) | |
In-hospital mortality at Day 60 | ||||||
Missing | 1 | 0 | 0 | 3 | 4 | |
No | 46 (62.2%) | 209 (72.6%) | 266 (70.9%) | 414 (66.3%) | 935 (68.7%) | |
Yes | 27 (36.5%) | 79 (27.4%) | 109 (29.1%) | 207 (33.2%) | 422 (31.0%) | |
Safety outcomes | 47 (63.5%) | 207 (71.9%) | 293 (78.1%) | 495 (79.3%) | 1042 (76.6%) | |
Arterial hypotension (at least one episode over D2-D14) | 45 (60.8%) | 204 (70.8%) | 287 (76.5%) | 488 (78.2%) | 1024 (75.2%) | |
At least one episode of hypernatremia > 155 mmol/L (over D2-D14) | ||||||
Missing | 1 | 0 | 2 | 0 | 3 | |
No | 67 (90.5%) | 284 (98.6%) | 362 (96.5%) | 600 (96.2%) | 1313 (96.5%) | |
Yes | 6 (8.1%) | 4 (1.4%) | 11 (2.9%) | 24 (3.8%) | 45 (3.3%) | |
At least one episode of hypokalemia < 2.8 mmol/L (over D2-D14) | ||||||
Missing | 1 | 0 | 1 | 0 | 2 | |
No | 67 (90.5%) | 264 (91.7%) | 351 (93.6%) | 576 (92.3%) | 1258 (92.4%) | |
Yes | 6 (8.1%) | 24 (8.3%) | 23 (6.1%) | 48 (7.7%) | 101 (7.4%) | |
Mesenteric ischemia or myocardial infarction | 0 (0.0%) | 0 (0.0%) | 7 (1.9%) | 7 (1.1%) | 14 (1.0%) | |
Mesenteric ischemia | 0 (0.0%) | 0 (0.0%) | 2 (0.5%) | 3 (0.5%) | 5 | (0.4%) |
Myocardial infarction | 0 (0.0%) | 0 (0.0%) | 5 (1.3%) | 4 (0.6%) | 9 (0.7%) | |
Renal damage over D3-D14 | ||||||
N/A | 0 | 2 | 6 | 22 | 30 | |
No RIFLE after D2 | 4 | 0 | 1 | 3 | 8 | |
No D1-D2 RIFLE | 0 | 1 | 1 | 4 | 6 | |
No | 58 (78.4%) | 230 (79.9%) | 298 (79.5%) | 467 (74.8%) | 1053 (77.4%) | |
Yes | 12 (16.2%) | 55 (19.1%) | 69 (18.4%) | 128 (20.5%) | 264 (19.4%) | |