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Table 2 Prognostic performance of the voxel-based quantitatively analysed parameters of ADC for the poor neurological outcome and comparison with GWR

From: Quantitative analysis of early apparent diffusion coefficient values from MRIs for predicting neurological prognosis in survivors of out-of-hospital cardiac arrest: an observational study

Parameters

Cut-off value

AUC (95% CI)

Sensitivity (95% CI)

Specificity (95% CI)

PPV (95% CI )

NPV (95% CI)

TP

FP

TN

FN

P valuea

CT

GWR

<1.11

0.69 (0.60–0.77)

18 (10–28)

100 (94–100)

100 (75–100)

48 (39–58)

12

0

57

62

reference

DW-MRI

Mean whole brain ADC value × 10−6 mm²/s

<739.2

0.83 (0.76–0.89)

51 (39–63)

100 (94–100)

100 (91–100)

61 (51–71)

37

0

57

37

0.01

ADC-PercentValue threshold, %

           

Threshold of ADC, × 10−6 mm²/s

 350

>2.2

0.80 (0.73–0.87)

31 (21–43)

100 (94–100)

100 (85–100)

53 (43–63)

23

0

57

51

0.04

 400

>3.4

0.81 (0.73–0.87)

34 (23–46)

100 (94–100)

100 (86–100)

54 (44–64)

25

0

57

49

0.03

 450

>5.2

0.82 (0.74–0.88)

38 (27–50)

100 (94–100)

100 (88–100)

55 (45–65)

27

0

57

47

0.02

 500

>7.8

0.82 (0.74–0.88)

41 (29–53)

100 (94–100)

100 (88–100)

56 (46–66)

30

0

57

44

0.02

 550

>11.7

0.81 (0.74–0.88)

43 (32–55)

100 (94–100)

100 (89–100)

58 (47–68)

32

0

57

42

0.03

 600

>17.2

0.81 (0.74–0.88)

51 (39–63)

100 (94–100)

100 (91–100)

61 (51–71)

38

0

57

36

0.03

  1. aP values are based on the DeLong test for comparison of the area under the receiver operating characteristic curve
  2. ADC apparent diffusion coefficient, GWR grey/white matter ratio, AUC area under the receiver operating characteristic curve, PPV positive predictive value, NPV negative predictive value, TP true positive, FP false positive, TN true negative, FN false negative, CI confidence interval, CT computed tomography, DW-MRI diffusion-weighted magnetic resonance image, ADC-PercentValue threshold percentage of voxel with ADC value below threshold