Table 1 Baseline characteristics of the patients
Characteristic | Haloperidol (n = 65) | Placebo (n = 67) |
|---|---|---|
Age, median (IQR), year | 66 (57–75.5) | 68 (60–74) |
Male, n (%) | 48 (74) | 42 (63) |
Location before ICU admission | ||
 Hospital ward, n (%) | 29 (45) | 31 (46) |
 Operation room/recovery, n (%) | 17 (26) | 18 (27) |
 ED, n (%) | 12 (19) | 11 (16) |
 Other, n (%) | 7 (11) | 7 (10) |
Type of ICU admission | ||
 Medical, n (%) | 36 (55) | 39 (58) |
 Emergency surgery, n (%) | 17 (26) | 17 (25) |
 Elective surgery, n (%) | 12 (19) | 11 (16) |
ICU admission diagnosis | ||
 Respiratory, n (%) | 24 (37) | 28 (42) |
 Gastrointestinal, n (%) | 14 (22) | 10 (15) |
 Cardiovascular, n (%) | 9 (14) | 16 (24) |
 Transplant, n (%) | 7 (11) | 5 (8) |
 Trauma, n (%) | 5 (8) | 1 (2) |
 Other, n (%) | 6 (9) | 7 (10) |
APACHE IV score, median (IQR) | 70 (57–90.5) | 77 (55–99) |
mSOFA score at randomization, median (IQR) | 5 (3–7)* | 6 (4–9) |
Baseline QTc at randomization, mean (SD) | 428.9 (29.9) | 421.3 (32.1) |
No. of days from ICU admission to randomization, median (IQR) | 4 (2–10.5) | 6 (3–9) |