Fig. 5

A Box plot depicting differences in whole blood cell type abundances between Subclass 1 and 2. Subclass 1 has significantly lower percentages of CD4 T cells (0.9 ± 1.5 vs. 5.2 ± 4.3; p < 0.001) and B cells (2.7 ± 2.0 vs. 4.6 ± 3.3; p = 0.024), and a higher percentage of endothelial cells compared to Subclass 2 (4.8 ± 0.7 vs. 4.2 ± 0.6). There were no significant differences in percentages of CD8 T cells between the two subclasses. B Number of TCR reads per 1 million RNA-Seq reads in septic shock subclasses. Subclass 1 had significantly fewer TCR reads normalized per RNA sequencing reads than Subclass 2 (3.91 ± 4.30 vs. 10/03 ± 8.46; p = 0.001). C Subclass 1 had significantly fewer mean clonotypes than Subclass 2 (59.70 ± 59.49 vs. 155.96 ± 138.4; p = 0.002). D Inverse Simpson index, a measure of mean diversity of the T cell repertoire, between Subclass 1 versus Subclass 2. Subclass 1 had a less diverse mean T cell repertoire than Subclass 2 on the Inverse Simpson index (43.84 ± 45.11 vs. 114.45 ± 108.8; p = 0.002)