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Table 3 Summary of the quality of evidence according to the Grading of Recommendation Assessment, Development, and Evaluation (GRADE)

From: Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses

Patient or population: Adult patients with expected trauma-induced coagulopathy

Settings: In-hospital care

Intervention: Patients treated with PCC

Comparison: Patients treated without PCC

 

Outcomes

No of participants (studies)

Odds ratio

Anticipated absolute effects

Certainty of the evidence (GRADE)

Comments

Without PCC

With PCC

Difference

Mortality

(8 studies,

n = 1685)

0.94

[0.60, 1.45]

27.2%

22.4%

−  4.8%

 ⊕  ⊝  ⊝  ⊝ 

Very lowa,b

May decrease in-hospital mortality

DVT

(6 studies,

n = 1497)

1.00

[0.64; 1.55]

5.3%

7.0%

 + 1.3%

 ⊕  ⊝  ⊝  ⊝ 

Very Lowa,c,d

May increase DVT

  1. aDowngraded because the overall risk of bias for observational studies was serious
  2. bDowngraded because PCC administration was not associated with mortality reduction in the only RCT published
  3. cDowngraded because of the large confidence intervals
  4. dDowngraded because the only RCT did not reported a significant increase of the DVT (but an increase of a composite outcome regrouping the occurrence of at least one thromboembolic event)
  5. DVT deep venous thrombosis, PCC prothrombin complex concentrate
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Critical Care

ISSN: 1364-8535