Table 2 Outcomes reported by included studies

Jehan

[26]

PCC + FFP: 10 (25)

FFP 26 (33)

p = 0.04*

PCC + FFP: 1 (2.5)

FFP: 1 (1.2)

p = 0.51*

Unclear

PCC + FFP: 7 (3)^µ

FFP: 9 (5)^µ

p < 0.04*

Unclear

PCC + FFP: 3 (3)^µ

FFP: 3 (3)^µ

p = 0.72*

Unclear

PCC + FFP: 5 (2)^µ

FFP: 7 (3)^µ

p = 0.03*

Proportion of patients with INR correction and time to INR correction from admission*

Rate of correction of INR*

Other TE*: PE, Mesenteric ischemia

ICU and Hospital LOS

Joseph

[31]

PCC + FFP: 15 (23)

FFP alone: 53 (28)

p = 0.04

PCC + FFP: 1 (1.6)

FFP alone: 2 (1.1)

p = 0.6*

Total

PCC + FFP: 6.6 (4.1)^µ

FFP alone: 10 (8.3)^µ

p = 0.001*

Total

PCC + FFP: 1.2 (2.1)^µ

FFP alone: 1.5 (2.7)^µ

p = 0.2*

Total

PCC + FFP: 2.8 (1.8)^µ

FFP alone: 3.9 (1.3)^µ

p = 0.01*

Proportion of patients with INR correction and time to INR correction from admission*

Time to treatment*

Mesenteric infarction*

ICU and Hospital LOS

Costs: therapy*, transfusion*, hospital

Joseph

[24]

PCC: 6 (22.3)

FFP 15 (27.8)

p = 0.78

PCC: 3 (11.1)

FFP: 4 (7.4)

p = 0.68*

Total

PCC: 3.2 (1.9)^µ

FFP: 5.4 (4.1)^µ

p = 0.009*

Total

PCC: 1.4 (2.3)^µ

FFP: 1.6 (2.4)^µ

p = 0.72*

Total

PCC: 5.1 (3.6)^µ

FFP: 90.7 (4.1)^µ

p = 0.005*

Proportion of patients with INR correction and time to INR correction from admission*

Time to treatment

Time to surgery

Mesenteric or myocardial infarction

ICU and Hospital LOS

Costs: therapy, transfusion, hospital, charges

Khurrum

[27]

PCC + WB: 39 (46)

WB 74 (44)

p = 0.72*

PCC + WB: 3 (4)

WB: 8 (5)

p = 0.75

At 24 h

PCC + WB: 8 (5–14)^$

WB: 10 (6–18)^$

p = 0.04*

At 24 h

PCC + WB: 2 (1–3)^$

WB: 2 (1–4)^$

p = 0.19*

At 24 h

PCC + WB: 6 (4–10)^$

WB: 8 (4–12)^$

p = 0.01*

PCC units

In ED mortality

ED, ICU and hospital LOS

AKI, ARDS, PE

Ponschab

[30]

–

–

At 24 h

All patients: 7 (3–10) [7]

At 24 h

All patients: 0 (0–00) [7]

At 24 h

All patients: 0 (0–0)⁷

ROTEM parameter

PCC unit, FC (g) and TXA (g) administrated at 24 h

Schlimp

[28]

PCC + FC: 18 (29)

FC: 7 (8)

PCC + FC + FFP: 5 (56)

p < 0.0001

–

At 24 h

PCC + FC: 8 (5–11)^$

FC: 3 (2–6)^$

PCC + FC + FFP: 21 (18–26)^$

p < 0.0001

At 24 h

PCC + FC: 0 (0–0)^$

FC: 0 (0–0)^$

PCC + FC + FFP: 4 (2–4)^$

p < 0.001

At 24 h

PCC + FC: none

FC: none

PCC + FC + FFP: 6 (6–10)^$

p = NA

Transfusion (RBC, FFP, platelet, FC, PCC) volume in ED and ICU

Massive transfusion

Standard and specific coagulation tests including ROTEM over 7 days

Schöchl

[29]

PCC + FC: 0 (0)

FC: 0 (0)

NCT: 0 (0)

-

At 24 h

PCC + FC: 8 (6–10.5)^$

FC: 3 (0–5)^$

NCT: 0 (0–2)^$

p < 0.001

At 24 h

PCC + FC: 0 (0–1)^$

FC: 0 (0–0)^$

NCT: 0 (0–0)^$

p < 0.001

At 24 h

PCC + FC: 0 (0–0)^$

FC: 0 (0–0)^$

NCT: 0 (0–0)^$

p = ns

PCC and FC unit transfused

Standard and specific coagulation tests including ROTEM over 7 days

Zeeshan

[25]

4F-PCC: 32 (26)

3F-PCC: 35 (28)

p = 0.78*

4F-PCC: 2 (1.4)

3F-PCC: 3 (2.1)

p = 0.81*

Total

4F-PCC: 7 (2)^µ

3F-PCC: 10 (3)^µ

p = 0.04*

Total

4F-PCC: 3 (3)^µ

3F-PCC: 3 (3)^µ

p = 0.23*

Total

4F-PCC: 6 (2)^µ

3F-PCC: 8 (2)^µ

p = 0.03*

Proportion of patients with INR correction and time to INR correction from admission*

ICU and Hospital LOS

Other TE*: Mesenteric infarction, PE

Costs: therapy, transfusion, total hospital

Zeeshan 2018

[26]

4-PCC + FFP: 41 (17.5)

FFP: 65 (27.7)

p = 0.01*

PCC + FFP: 8 (3.4)

FFP: 13 (5.5)

p = 0.11

At 24 h

PCC + FFP: 6 (4)^µ

FFP: 10 (4)^µ

p = 0.02*

At 24 h

PCC + FFP: 3 (2)^µ

FFP: 3 (3)^µ

p = 0.72*

At 24 h

PCC + FFP: 3 (2)^µ

FFP: 6 (3)^µ

p = 0.01*

ED mortality*

Transfusion at 4 h*

ICU and Hospital LOS

Skilled nursing facility or rehab. disposition

Complications: AKI, ARDS, PE