Table 1 Baseline characteristics
From: Subphenotypes in patients with acute respiratory distress syndrome treated with high-flow oxygen
Overall (n = 41) | Hypoinflammatory subphenotype (n = 24) | Hyperinflammatory Subphenotype (n = 17) | p value | |
|---|---|---|---|---|
Sex (female), n (%) | 10 (24.4) | 4 (16.7) | 6 (35.3) | 0.318 |
Age (year), median [IQR] | 60 [50, 68] | 61 [50, 67] | 60 [51, 72] | 0.761 |
Comorbidities, n (%) | ||||
Arterial hypertension | 18 (43.9) | 14 (58.3) | 4 (23.5) | 0.058 |
Diabetes | 12 (29.3) | 8 (33.3) | 4 (23.5) | 0.740 |
Cardiovascular diseases | 6 (14.6) | 4 (16.7) | 2 (11.8) | 1.000 |
COPD | 4 (9.8) | 2 (8.3) | 2 (11.8) | 1.000 |
ARDS etiology, n (%) | 0.148 | |||
Pneumonia | 31 (75.6) | 19 (79.2) | 12 (70.6) | |
Other | 5 (12.2) | 4 (16.7) | 1 (5.9) | |
Pancreatitis | 2 (4.9) | 1 (4.2) | 1 (5.9) | |
Extrapulmonary sepsis | 3 (7.3) | 0 (0.0) | 3 (17.6) | |
APACHE_II, median [IQR]) | 18 [14, 22] | 15 [13, 21] | 20 [17, 22] | 0.058 |
At the time of ARDS diagnosis | ||||
SOFA, median [IQR] | 6 [4, 8] | 6 [4, 8] | 6 [5, 8] | 0.758 |
PaO2/FiO2, median [IQR] | 96 [79, 116] | 86 [70, 114] | 107 [88, 125] | 0.179 |
FiO2, median [IQR] | 0.85 [0.70, 1] | 0.80 [0.70, 1] | 0.85 [0.60, 1] | 0.742 |
Flow (L min−1), median [IQR] | 60 [53, 60] | 60 [53, 60] | 60 [55, 60] | 0.844 |
Respiratory rate, median [IQR] | 26 [21, 32] | 24 [21, 30] | 30 [25, 34] | 0.107 |
pH, median [IQR] | 7.43 [7.40, 7.47] | 7.44 [7.41, 7.47] | 7.43 [7.39, 7.44] | 0.087 |
PaCO2 (mmHg), median [IQR] | 36 [32, 43] | 36 [32, 40] | 37 [31, 44] | 0.750 |
Leukocytes (×106 L−1), median [IQR] | 11.1 [7.2, 14.3] | 11.8 [7.8, 14.5] | 8.2 [4.0, 13.5] | 0.361 |