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Table 1 Blood gas analyses and partitioned respiratory mechanics of the AE-ILD-UIP and the ARDS population at different PEEP levels. Data are presented as median value and IQR

From: Physiological effects of lung-protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study

Variable

AE-ILD-UIP

ARDS

p-value

ZEEP phase

   

EL, cmH2O/L

44.4 (39.7–50.7)

17.9 (9.9–23.3)

 < 0.0001

Ecw, cmH2O/L

3.2 (2.5–5.7)

5.4 (4–7.4)

0.12

Etot, cmH2O/L

49 (43.9–54.7)

22 (16.8–28)

 < 0.0001

PL,EI, cmH2O

16.7 (14.8–19)

4.4 (2.9–6.3)

 < 0.0001

PL,EE, cmH2O

 − 4.3 (− 7.6– − 2.3)

 − 4.1 (− 7.6– − 2.9)

0.66

ΔPaw, cmH2O

16.8 (13.8–19.3)

14.4 (11.5–21.2)

0.56

ΔPL, cmH2O

21.1 (17.8–23.6)

9.3 (7–11.5)

 < 0.0001

pH, value

7.42 (7.41–7.42)

7.4 (7.37–7.41)

0.07

pO2, cmH2O

74 (66.5–80)

83 (75–89)

0.3

pCO2, cmH2O

39.5 (38–45)

39 (36.8–40)

0.06

PEEPLOW phase

   

EL, cmH2O/L

43.3 (36.8–53)

14.6 (12.2–19.1)

 < 0.0001

Ecw, cmH2O/L

3.4 (2.3–5.6)

5.7 (4.3–8.3)

0.09

Etot, cmH2O/L

48.5 (40–56.8)

22.1 (19.1–25.2)

 < 0.0001

PL,EI, cmH2O

15.3 (11.3–18.7)

10.5 (5–14)

0.01

PL,EE, cmH2O

 − 2.6 (− 4.3– − 1.2)

 − 2.5 (− 4.6– − 0.5)

0.75

ΔPaw, cmH2O

16.8 (14.3–18.6)

15.1 (11.9–21.4)

0.9

ΔPL, cmH2O

18.4 (15.6–21.8)

12.3 (8.5–16.6)

0.02

PEEP, cmH2O

4 (4–4)

4 (4–5)

0.2

pH, value

7.41 (7.38–7.42)

7.4 (7.36–7.42)

0.3

pO2, cmH2O

93.5 (73.3–107)

74.5 (68.3–80.5)

0.1

pCO2, cmH2O

41 (38.5–42)

42 (39.8–47)

0.18

PEEPTITRATED phase

   

EL, cmH2O/L

48.8 (59–42.8)

15.2 (12.4–19.7)

 < 0.0001

Ecw, cmH2O/L

3.7 (3.2–5.9)

5.7 (4.7–7.2)

0.1

Etot, cmH2O/L

55.3 (45.9–62.5)

20.6 (19–24.5)

 < 0.0001

PL,EI, cmH2O

23.3 (21.3–26.7)

16.9 (13.5–19.2)

0.001

PL,EE, cmH2O

0.8 (0.3–1.5)

2.4 (0.6–4.9)

0.04

ΔPaw, cmH2O

19.1 (16.1–21.6)

15.3 (9.4–17)

0.01

ΔPL, cmH2O

22.6 (20.8–25.8)

13.9 (6.6–16.5)

0.0001

PEEP, cmH2O

12 (10–14)

14 (12––17.5)

0.03

pH, value

7.38 (7.35–7.4)

7.37 (7.34–7.4)

0.34

pO2, cmH2O

80 (58–93)

105 (80–134)

0.01

pCO2, cmH2O

42 (39.5–43.3)

45 (40–48)

0.08

  1. AE-ILD-UIP, acute exacerbation of interstitial lung disease with usual interstitial pneumonia pattern; ARDS, acute respiratory distress syndrome; IQR, interquartile range; ΔPL, transpulmonary driving pressure; PL,EI, end-inspiratory transpulmonary pressure; PL,EE, end-expiratory transpulmonary pressure; ΔPaw, driving pressure; Etot, respiratory system elastance; Ecw, chest wall elastance; EL, lung elastance; PEEP, positive end-expiratory pressure