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Table 1 Baseline demographics in AKI patients

From: The impact of higher protein dosing on outcomes in critically ill patients with acute kidney injury: a post hoc analysis of the EFFORT protein trial

Characteristic

All patients

High protein

Usual protein

N

312

163

149

Age (years)

(312) 60.7 ± 14.6 (20.0–95.0)

(163) 60.8 ± 13.6 (22.0–95.0)

(149) 60.6 ± 15.7 (20.0–93.0)

Sex

Male

191 (61.2%)

102 (62.6%)

89 (59.7%)

Female

120 (38.5%)

61 (37.4%)

59 (39.6%)

Admission status

Medical

278 (89.1%)

144 (88.3%)

134 (89.9%)

Surgical elective

11 (3.5%)

5 (3.1%)

6 (4.0%)

Surgical emergency

23 (7.4%)

14 (8.6%)

9 (6.0%)

ICU admission status

Baseline SOFA score

(312) 9.7 ± 3.7 (0.0–22.0)

(163) 9.7 ± 3.5 (0.0–18.0)

(149) 9.7 ± 3.9 (0.0–22.0)

APACHE II score

(298) 23.7 ± 8.0 (6.0–55.0)

(155) 23.7 ± 7.6 (6.0–45.0)

(143) 23.7 ± 8.3 (6.0–55.0)

NUTRIC score

(298) 5.4 ± 1.7 (0.0–9.0)

(155) 5.3 ± 1.6 (0.0–9.0)

(143) 5.4 ± 1.9 (1.0–9.0)

Frailty

(284) 3.9 ± 1.6 (1.0–8.0)

(152) 3.9 ± 1.6 (1.0–8.0)

(132) 3.9 ± 1.7 (1.0–8.0)

Frailty (clinical frailty scale ≥ 5)

94 (30.1%)

48 (29.4%)

46 (30.9%)

Patients received renal replacement therapies on randomization day

Yes

69 (22.1%)

39 (23.9%)

30 (20.1%)

No

243 (77.9%)

124 (76.1%)

119 (79.9%)

Patients ever received KRT post randomization

Yes

107 (34.3%)

60 (36.8%)

47 (31.5%)

No

205 (65.7%)

103 (63.2%)

102 (68.5%)

Patients ever versus never dialyzed

Yes

116 (37.2%)

65 (39.9%)

51 (34.2%)

No

196 (62.8%)

98 (60.1%)

98 (65.8%)

Acute kidney injury*

Stage 1

120 (38.5%)

59 (36.2%)

61 (40.9%)

Stage 2

74 (23.7%)

43 (26.4%)

31 (20.8%)

Stage 3

118 (37.8%)

61 (37.4%)

57 (38.3%)

Chronic kidney disease

Yes

63 (20.2%)

35 (21.5%)

28 (18.8%)

No

249 (79.8%)

128 (78.5%)

121 (81.2%)

  1. Values reported as n (%), (n) mean ± SD (min–max)
  2. *Acute kidney injury: KDIGO Stage 1: ≥ 26.52 µmol/L increase within 48 h or 1.5–1.9 times baseline within 7 days; Stage 2: 2.0–2.9 times baseline within 7 days; Stage 3: ≥ 3 times baseline within 7 days or increase to ≥ 353.6 µmol/L with an acute increase of > 44.2 µmol/L
  3. Chronic kidney disease: Defined in comorbidities as moderate renal disease: creatinine clearance 51–85 mL/min; and severe renal disease: creatinine clearance less than 50 mL/min and not on dialysis