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Fig. 6 | Critical Care

Fig. 6

From: Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction

Fig. 6

S100A8/A9 blockade improves LPS-induced mitochondrial dysfunction in the heart. A Experimental layout. B Citrate synthase activity. C Mitochondrial yield. D Oxygen consumption rate (OCR) after incubation with respiratory substrates (malate + glutamate) feeding complex I, either in the absence (state 2) or presence (state 3) of ADP. E Oxygen consumption rate after incubation with respiratory substrates (succinate + rotenone) feeding complex II. Differences between three groups were tested using 1-way ANOVA with Fisher’s LSD Test. Normality assessment was performed with Shapiro–Wilk test. LPS, Lipopolysaccharide; ABR, ABR-238901; OCR, Oxygen consumption rate. Data are represented as mean ± SD from N = 4–7 per group

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Critical Care

ISSN: 1364-8535