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Table 2 Gas exchange and respiratory mechanics

From: Advanced respiratory mechanics assessment in mechanically ventilated obese and non-obese patients with or without acute respiratory distress syndrome

 

All patients n = 149

Non-obese Non-ARDS n = 41

Non-obese ARDS n = 56

Obese non-ARDS n = 18

Obese ARDS n = 34

Overall comparison p-value

RR—min−1

25 [20–29]

20 [19–25]

26 [23–29]***

24 [20–27]

30 [24–29]***

 < 0.001

VE—L min−1

9.6 [7.7–11.3]

8.4 [6.8–10.2]

9.9 [8–11.0]*

9.2 [8.2–9.9]

10.8 [9.5–11.9]**

0.002

FiO2—%

50 [30–70]

30 [24–37]

60 [40–80]***

60 [40–60]**

52 [40–70]***

 < 0.001

PaO2—mmHg

79 [69–96]

88 [69–129]

74 [63–87]*

74 [71–94]

82 [70–91]

0.038

PaO2/FiO2—mmHg

183 [120–255]

314 [243–378]

129 [100–188]***

174 [121–242]***

157 [121–208]***

 < 0.001

PaCO2—mmHg

40 [35–47]

36 [32–37]

41 [35–50]*

40 [37–48]

42 [39–46]**

0.009

Ventilatory ratio

1.3 [1.6–2]

1.3 [1.1–1.5]

1.8 [1.4–2.3]***

1.8 [1.1–2.2]

1.9 [1.6–2.1]***

 < 0.001

Patients with complete airway closure > 5 cmH2O—n

35 (23.5)

4 (9.8)

10 (17.9)

4 (22.2)

17 (50.0) **, #

 < 0.001

AOP in patients with complete airway closure > 5 cmH2O—cmH2O

8.5 [7.5–11]

9.5 [6.5–12.5]

9 [7.5–11]

8.5 [7–10]

8.5 [8–10]

0.84

PEEPtot—cmH2O

6 [5.5–7.5]

5.5 [5–6]

6 [5.5–7.5]

6.5 [5.5–6.5]

7.5 [6–9.5]***, ##, $$

 < 0.001

PPlat—cmH2O

15 [13–18]

12.5 [11–14.5]

15.5 [13.5–18.5]***

15.5 [14–16.5]*

17 [15–20.5]***

 < 0.001

CRS—mL cmH2O−1

44 [36–56]

55 [45–73]

41 [31–51]**

41 [36–51]*

43 [35–53]**

 < 0.001

CRS-AOP—mL cmH2O−1

46 [36–57]

56 [45–73]

41 [31–51]**

41 [36–52]*

43 [36–54]*

 < 0.001

DPRS—cmH2O

8.5 [7–11]

6.5 [5.5–8.5]

9 [6.5–11.5]***

9.5 [8.5–10]**

9 [7.5–11]**

 < 0.001

DPRS-AOP—cmH2O

8.5 [6.5–10]

6.5 [5.5–8.5]

9.0 [6.5–11.5]**

9 [7.5–10.0]**

8.5 [7.5–10.5]**

 < 0.001

RRS—cmH2O L−1 s−1

17 [14–21]

16 [14.5–21]

16.5 [13.5–20]

17 [14–18.5]

18 [14.5–22.5]

0.34

ΔP1–PPlat—cmH2O

2.1 [1.1–3.4]

1.3 [0.9–2.7]

2.4 [1.3–4.2]

2.3 [1.7–2.9]

2.8 [1.1–5.2]

0.128

DPL—cmH2O

5 [4–7.5]

4 [3–6]

5.5 [4–8.5]*

6.5 [5.5–8]*

5.5 [4.5–7.5]*

0.005

PPlat Lung—cmH2O

9.5 [7.5–12.5]

7.5 [6–9.5]

10 [8–13]*

11 [9.5–13]*

11 [9–12.5]**

0.002

Lung Stress—cmH2O

10 [7.5–14.5]

8 [4–10.5]

10 [8–14]*

14.5 [13.5–16.5]**

12.5 [9–16]*

0.002

  1. Data are presented as median [interquartile range] or number (percentage)
  2. RR, Respiratory Rate; VE, Minute ventilation; FiO2, Fraction of inspired oxygen; PaO2, Partial pressure of arterial oxygen; PaCO2, Partial pressure of arterial carbon dioxide; AOP, Airway Opening Pressure; PEEPtot, Total Positive End-Expiratory Pressure; PPlat, Plateau Pressure; CRS, Respiratory System Compliance; CRS-AOP, CRS using AOP instead of PEEPtot in the calculation; DPRS, Respiratory System Driving Pressure; DPRS-AOP, DPRS using AOP instead of PEEPtot in the calculation; RRS, Respiratory System Resistance; ΔP1–PPlat, Difference between P1 and PPlat with P1 defined as airway pressure at first zero flow; DPL, Lung Driving Pressure; PPlat Lung, Plateau Pressure of the Lung. Lung stress was defined as the difference between PPlat Lung and the expiratory transpulmonary pressure
  3. *p < 0.05, **p < 0.01, ***p < 0.001 compared to non-obese non-ARDS patients, #p < 0.05, ##p < 0.01, ###p < 0.001 compared to non-obese ARDS patients; $$p < 0.01 compared to obese non-ARDS patients