Table 1 Main characteristics of the patients
All patients n = 149 | Non-obese non-ARDS n = 41 | Non-obese ARDS n = 56 | Obese non-ARDS n = 18 | Obese ARDS n = 34 | Overall comparison p-value | |
|---|---|---|---|---|---|---|
Age—years | 65 [56–77] | 69 [56–80] | 64 [53–74] | 66 [62–75] | 64 [59–76] | 0.65 |
Male sex—n | 91 (61.1) | 25 (61.0) | 32 (57.1) | 12 (66.7) | 22 (64.7) | 0.85 |
Height—cm | 168 [160–174] | 168 [159–174] | 166 [160–175] | 167 [161–174] | 170 [163–174] | 0.65 |
BMI—kg m−2 | 26 [23–31] | 24 [21–24] | 24 [22–25] | 34 [30–36]***, ### | 34 [31–37]***, ### | < 0.001 |
Abdominal perimeter—cm | 104 [93–115] | 93 [83–98] | 98 [93–107] | 116 [110–119]**, ## | 120 [115–134]**, ### | < 0.001 |
SOFA at enrollment | 8 [6–11] | 7 [6–9] | 10 [6–12] | 8 [6–9] | 8 [5–10] | 0.087 |
Non-pulmonary SOFA at enrollment | 5 [3.5–8] | 5 [4–7] | 6 [4–8] | 5 [4–6] | 4 [2–7] | 0.35 |
SAPS II at enrollment | 50 [39–63] | 50 [40–63] | 52 [40–66] | 50 [38–70] | 46 [35–57] | 0.55 |
Chronic pulmonary disease—n | 36 (24.2) | 8 (19.5) | 7 (12.5) | 6 (33.3) | 15 (44.1) # | 0.012 |
Immunodepression—n | 18 (12.1) | 5 (12.2) | 10 (17.9) | 1 (5.6) | 2 (5.9) | 0.294 |
Cause of ICU admission—n | ||||||
Pneumonia | 57 (38.3) | 3 (7.3) | 37 (66.1) *** | 0 (0) ### | 17 (50) ***,§§ | < 0.001 |
Hydrostatic pulmonary edema | 14 (9.4) | 6 (14.6) | 0 (0)* | 8 (44.4) ### | 0 (0) §§§ | < 0.001 |
Non-pulmonary Sepsis | 21 (14.1) | 6 (14.6) | 7 (12.5) | 0 (0) | 8 (14.8) | 0.134 |
Acute exacerbation of obstructive pulmonary disease | 3 (2) | 3 (7.3) | 0 (0) | 0 (0) | 0 (0) | 0.045 |
Neurologic conditions/coma | 28 (18.8) | 17 (41.5) | 3 (5.4)*** | 6 (33.3) ## | 2 (3.7)** | < 0.001 |
Metabolic disorder | 3 (2) | 0 (0) | 1 (1.8) | 2 (11.1) | 0 (0) | 0.028 |
Other | 23 (15.4) | 6 (14.6) | 8 (14.3) | 2 (11.1) | 7 (13) | 0.795 |
Survival at day 60—n | 101 (67.8) | 33 (80.5) | 31 (55.4) | 13 (72.2) | 24 (70.6) | 0.064 |
Number of ventilator-free days at day 28—days | 13 [0–23] | 23 [0–26] | 1 [0–18]*** | 19 [2–25]# | 12 [0–19]* | < 0.001 |