Table 1 Baseline demographics, stratified by nadir platelet count during ECMO
Variable | Overall (N = 419) | Normal (N = 20) | Mild (N = 60) | Moderate (N = 159) | Severe (N = 179) | P-value | Post hoc |
|---|---|---|---|---|---|---|---|
Age, years | 57 [47–66] | 55 [46–61] | 57 [43–67] | 58 [47–67] | 57 [47–67] | 0.43 | n.s |
BMI, kg/m2 | 27.0 [24.3–30.6] | 29.5 [26.2–32.0] | 26.9 [24.0–30.7] | 27.1 [24.6–30.4] | 26.8 [24.2–30.4] | 0.22 | n.s |
Female | 154 (37) | 7 (35) | 19 (32) | 48 (30) | 80 (45) | 0.04 | Severe versus moderate* |
Medical history | |||||||
Hypertension | 139 (62) | 7 (35) | 13 (25) | 53 (33) | 66 (37) | 0.74 | n.s |
Diabetes mellitus | 68 (30) | 8 (40) | 13 (25) | 20 (13) | 27 (15) | < 0.001 | Severe versus mild*/normal** moderate versus normal** |
Myocardial infarction | 76 (34) | 4 (20) | 9 (15) | 32 (20) | 31 (17) | 0.76 | n.s |
Asthma/COPD | 37 (55) | 3 (15) | 6 (10) | 19 (12) | 9 (5) | 0.22 | n.s |
Chronic kidney disease | 25 (6) | 0 (0) | 4 (7) | 7 (4) | 14 (8) | 0.38 | n.s |
Day of ECMO initiation | |||||||
SOFA-score | 11 [8–13] | 9 [8–10] | 10 [8–12] | 10 [8–13] | 13 [10–14] | < 0.001 | Severe versus mild/moderate/normal** |
Lactate, mmol/L | 5.2 [2.4–10.0] | 3.6 [1.6–5.6] | 2.5 [1.8–8.1] | 4.2 [2.1–12] | 6.6 [3.4–10.4] | < 0.01 | Severe versus mild/normal* |
Hb, g/dL | 11.6 [9.5–13.5] | 11.4 [9.5–13.7] | 12.0 [10.3–13.7] | 11.8 [9.3–13.6] | 11.0 [9.4–13.4] | 0.59 | n.s |
Platelet count | 179 [119–253] | 324 [254–379] | 216 [155–264] | 199 [142–255] | 133 [82–197] | < 0.001 | Moderate versus normal *** mild versus normal *** severe versus mild/moderate/normal*** |
Difference in platelet count day of initiation -nadir platelet count at first day of ECMO | 49 [6–102] | 66 [− 1 to 105] | 28 [0–66] | 50 [9.5–93] | 51 [16–112] | 0.42 | n.s |
ECMO characteristics | |||||||
Duration, days | 5 [3–8] | 3 [2–4] | 4 [2–7] | 4 [3–8] | 6 [4–9] | < 0.001 | Moderate versus normal* severe versus mild**/moderate*/normal** |
Second run | 38 (9) | 1 (5) | 3 (5) | 12 (8) | 22 (12) | 0.23 | n.s |
Peripheral cannulation configuration | 355 (86) | 20 (100) | 55 (92) | 133 (84) | 147 (84) | 0.10 | n.s |
Surgical cannulation | 226 (56) | 11 (55) | 23 (40) | 86 (56) | 106 (60) | 0.06 | n.s |
Distal leg perfusion cannula | 288 (71) | 15 (79) | 42 (72) | 106 (69) | 125 (71) | 0.84 | n.s |
ECPR | 106 (26) | 3 (15) | 20 (33) | 41 (26) | 42 (24) | 0.36 | n.s |
Main reason of ECMO initiation | 0.04 | n.s | |||||
Acute myocardial infarction | 116 (28) | 5 (25) | 15 (25) | 49 (31) | 47 (26) | ||
Post-cardiotomy | 113 (27) | 1 (5) | 11 (18) | 43 (27) | 58 (32) | ||
Other | 189 (45) | 14 (70) | 34 (57) | 67 (42) | 74 (41) |