From: Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months
Prediction of GOSE | 3 Month | 12 Month | ||||
---|---|---|---|---|---|---|
Patients characteristics and clinical information | unfavorable outcome (n = 35) | Favorable outcome (n = 9) | p value | Unfavorable outcome (n = 14) | Favorable outcome (n = 15) | p value |
Sex (male/female) | 30/5 | 6/3 | 0.42 | 11/3 | 13/2 | 0.82 |
Age (mean ± SD) | 55.4 ± 20.4 | 40.5 ± 21.0 | 0.03 | 52.0 ± 18.7 | 38 ± 19.8 | 0.06 |
Weight (mean ± SD) | 88.5 ± 19.5 | 76.4 ± 21.1 | 0.08 | 81.7 ± 22.6 | 79.3 ± 16.1 | 0.75 |
Injury severity score (ISS) (mean ± SD) | 56.4 ± 22.6 | 35.1 ± 12.6 | < 0.01 | 35.5 ± 12.5 | 36.4 ± 12.5 | 0.81 |
Admission-type ER ICU | 13 (37.1%) 21 (60%) | 2 (22.2%) 7 (77.7%) | 0.36 | 4 (28.5%) 10 (71.4%) | 4 (26.6%) 11 (73.3%) | 0.58 |
Hypoxia (yes/no) * | 8/22 | 0/9 | 0.07 | 3/8 | 1/14 | 0.38 |
Intubated (yes/no) * | 21/13 | 7/2 | 0.61 | 11/3 | 10/5 | 0.77 |
Hypotension (yes/no) * | 5/25 | 1/7 | 0.98 | 2/10 | 2/13 | 0.64 |
Paralytic-AGT (yes/No) * | 16/17 | 6/1 | 0.40 | 6/7 | 9/4 | 0.32 |
Loss consciousness* | 25/4 | 5/2 | 0.30 | 13/0 | 8/2 | 0.48 |
Location of injury ŧ | 0.70 | 0.52 | ||||
Type of injury ŧ | 0.24 | 0.21 | ||||
GCS (total) (mean ± SD) | 5.3 ± 2.17 | 5.3 ± 2.5 | 0.95 | 4.5 ± 1.9 | 5.8 ± 2.3 | 0.11 |
GCS-motor GCS-eye (mean ± SD) GCS-verbal | 2.9 ± 1.9 1.5 ± 1.1 1.0 ± 0.75 | 2.4 ± 2.2 1.0 ± 0.0 1.1 ± 0.78 | 0.54 0.14 0.94 | 2.28 ± 2.0 1.4 ± 0.99 0.71 ± 0.48 | 2.7 ± 2.1 1.6 ± 1.3 1.13 ± 0.74 | 0.57 0.68 0.08 |
GCS 3–4 GCS 5–6 (mean ± SD) GCS 7–8 | 15 (42.5%) 6 (14.1%) 14 (40%) | 5 (55.5%) 0 4 (44.4%) | 0.80 | 9 (64.2%) 1 (7.1%) 4 (28.5%) | 6 (40%) 1 (6.6%) 8 (53.3%) | 0.62 |
CT findings** Diffuse axonal injury Mid shift Skull fracture Cerebral edema Contusion Intracranial hemorrhage Epidural hemorrhage Subdural hemorrhage Arachnoid hemorrhage Marshall score I II III IV V | 5/20 6/18 209/6 6/20 14/12 18/8 3/23 20/6 22/4 0 17 4 3 2 | 0/7 4/3 3/4 0/7 2/5 3/4 0/7 5/2 5/2 0 3 1 0 3 | 0.57 0.41 0.30 0.24 0.33 0.53 0.62 0.34 0.37 0.19 | 2/7 4/4 7/2 3/6 3/6 5/4 7/2 8/2 6/3 0 4 1 3 1 | 2/11 6/7 9/4 2/11 7/6 8/5 9/4 8/4 8/5 0 6 2 1 4 | 0.62 0.16 0.52 0.49 0.47 0.63 0.11 0.86 0.16 0.37 |