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Table 2 Patient demographics and clinical characteristics for unfavorable (GOSE 1–4) and favorable (GOSE 5–8) outcome groups at 3 and 12 months

From: Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months

Prediction of GOSE

3 Month

12 Month

Patients characteristics and clinical information

unfavorable outcome (n = 35)

Favorable outcome (n = 9)

p value

Unfavorable outcome (n = 14)

Favorable outcome (n = 15)

p value

Sex (male/female)

30/5

6/3

0.42

11/3

13/2

0.82

Age (mean ± SD)

55.4 ± 20.4

40.5 ± 21.0

0.03

52.0 ± 18.7

38 ± 19.8

0.06

Weight (mean ± SD)

88.5 ± 19.5

76.4 ± 21.1

0.08

81.7 ± 22.6

79.3 ± 16.1

0.75

Injury severity score (ISS) (mean ± SD)

56.4 ± 22.6

35.1 ± 12.6

 < 0.01

35.5 ± 12.5

36.4 ± 12.5

0.81

Admission-type

 ER

 ICU

13 (37.1%)

21 (60%)

2 (22.2%)

7 (77.7%)

0.36

4 (28.5%)

10 (71.4%)

4 (26.6%)

11 (73.3%)

0.58

Hypoxia (yes/no) *

8/22

0/9

0.07

3/8

1/14

0.38

Intubated (yes/no) *

21/13

7/2

0.61

11/3

10/5

0.77

Hypotension (yes/no) *

5/25

1/7

0.98

2/10

2/13

0.64

Paralytic-AGT (yes/No) *

16/17

6/1

0.40

6/7

9/4

0.32

Loss consciousness*

25/4

5/2

0.30

13/0

8/2

0.48

Location of injury ŧ

  

0.70

  

0.52

Type of injury ŧ

  

0.24

  

0.21

 GCS (total) (mean ± SD)

5.3 ± 2.17

5.3 ± 2.5

0.95

4.5 ± 1.9

5.8 ± 2.3

0.11

 GCS-motor

 GCS-eye (mean ± SD)

 GCS-verbal

2.9 ± 1.9

1.5 ± 1.1

1.0 ± 0.75

2.4 ± 2.2

1.0 ± 0.0

1.1 ± 0.78

0.54

0.14

0.94

2.28 ± 2.0

1.4 ± 0.99

0.71 ± 0.48

2.7 ± 2.1

1.6 ± 1.3

1.13 ± 0.74

0.57

0.68

0.08

 GCS 3–4

 GCS 5–6 (mean ± SD)

 GCS 7–8

15 (42.5%)

6 (14.1%)

14 (40%)

5 (55.5%)

0

4 (44.4%)

0.80

9 (64.2%)

1 (7.1%)

4 (28.5%)

6 (40%)

1 (6.6%)

8 (53.3%)

0.62

CT findings**

  Diffuse axonal injury

  Mid shift

  Skull fracture

  Cerebral edema

 Contusion

 Intracranial hemorrhage

  Epidural hemorrhage

  Subdural hemorrhage

  Arachnoid hemorrhage

 Marshall score

 I

 II

 III

 IV

 V

5/20

6/18

209/6

6/20

14/12

18/8

3/23

20/6

22/4

0

17

4

3

2

0/7

4/3

3/4

0/7

2/5

3/4

0/7

5/2

5/2

0

3

1

0

3

0.57

0.41

0.30

0.24

0.33

0.53

0.62

0.34

0.37

0.19

2/7

4/4

7/2

3/6

3/6

5/4

7/2

8/2

6/3

0

4

1

3

1

2/11

6/7

9/4

2/11

7/6

8/5

9/4

8/4

8/5

0

6

2

1

4

0.62

0.16

0.52

0.49

0.47

0.63

0.11

0.86

0.16

0.37

  1. *The variables are based on the number of patients. ŧ These data included several variables that have not been shown in detail for each cohort. There was no significant difference for any type and location of injury between cohorts with favorable and unfavorable outcomes at 3- and 12 months post-injury
  2. *Shows the number of patients that had intubation and mentioned physiological conditions in each unfavorable and favorable group. ŧ the details have not been shown due to several conditions and table limitation. ** shows the number of patients that had brain damage captured on CT for unfavorable and favorable group