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Table 4 Change in endotypes over time in ICU and subsequent outcomes

From: Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study

Variable

Endotype change

p valuee

Adaptive to adaptive (N = 60)a

Adaptive to I/C* (N = 24)b

I/C to adaptive (N = 38)c

I/C to I/C (N = 74)d

In-hospital mortality

0 (0%)

2 (8.3%)

1 (2.6%)

3 (4.1%)

0.15

30-day mortality

1 (1.7%)

4 (16.7%)

2 (5.3%)

7 (9.5%)

0.06

90-day mortality

2 (3.3%)

5 (20.8%)

3 (7.9%)

9 (12.2%)

0.07

CCI

1 (1.7%)

1 (4.2%)

5 (13.2%)

10 (13.5%)

0.04

Poor discharge disposition

7 (11.7%)

7 (30.4%)

8 (21.1%)

16 (21.9%)

0.2

 Missing

0

1

0

1

 

Total ICU LOS (days)

2 (1, 4)

6.5 (2, 8)

4 (2, 8)

5 (2, 11)

 < 0.001

 Missing

0

2

0

0

 
  1. aFirst and last endotypes are both adaptive
  2. bFirst endotype was adaptive; last endotype was inflammopathic or coagulopathic
  3. cFirst endotype was inflammopathic or coagulopathic; last endotype was adaptive
  4. dFirst and last endotypes are both inflammopathic and coagulopathic
  5. eFisher’s exact test; Kruskal–Wallis rank sum test
  6. *I/C Inflammopathic/coagulopathic, ICU intensive care unit, LOS length of stay
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