Table 3 Endotypes and outcomes on ICU admission
Variable | Septic (N = 377) | Non-septic (N = 145) | ||||||
|---|---|---|---|---|---|---|---|---|
Adaptive (N = 151)a | Coagulopathic (N = 97)a | Inflammopathic (N = 129)a | p valueb | Adaptive (N = 74)a | Coagulopathic (N = 48)a | Inflammopathic (N = 23)a | p valueb | |
Secondary infection | 30 (19.9%) | 36 (37.1%) | 48 (37.2%) |  < 0.01 | 4 (5.4%) | 2 (4.2%) | 6 (26.1%) |  < 0.01 |
CCI | 40 (26.5%) | 38 (39.2%) | 44 (34.1%) | 0.1 | 2 (2.7%) | 2 (4.2%) | 6 (26.1%) |  < 0.01 |
Adverse outcome | 63 (41.7%) | 63 (65.6%) | 87 (67.4%) |  < 0.001 | 18 (24.7%) | 10 (20.8%) | 12 (52.2%) | 0.02 |
 Missing | 0 | 1 | 0 |  | 1 | 0 | 0 |  |
Poor discharge disposition | 49 (32.5%) | 42 (43.8%) | 61 (47.3%) | 0.03 | 12 (16.4%) | 7 (14.6%) | 4 (17.4%) | 0.95 |
 Missing | 0 | 1 | 0 |  | 1 | 0 | 0 |  |
In-hospital mortality | 7 (4.6%) | 6 (6.2%) | 15 (11.6%) | 0.07 | 2 (2.7%) | 1 (2.1%) | 0 (0%) |  > 0.99 |
30-day mortality | 11 (7.4%) | 9 (9.5%) | 18 (14%) | 0.19 | 4 (5.4%) | 1 (2.1%) | 1 (4.4%) | 0.74 |
 Missing | 2 | 2 | 0 |  |  |  |  |  |
90-day mortality | 22 (15.2%) | 16 (17%) | 23 (18.4%) | 0.78 | 5 (6.8%) | 2 (4.2%) | 1 (4.4%) | 0.89 |
 Missing | 6 | 3 | 4 |  |  |  |  |  |
IMX-SEV severity risk band |  |  |  |  < 0.001 |  |  |  |  < 0.001 |
 Low | 38 (25.2%) | 0 (0%) | 0 (0.00%) |  | 15 (20.3%) | 1 (2.1%) | 0 (0%) |  |
 Moderate | 113 (74.8%) | 72 (74.2%) | 65 (50.4%) |  | 59 (79.7%) | 47 (97.9%) | 18 (78.3%) |  |
 High | 0 (0.0%) | 25 (25.8%) | 64 (49.6%) |  | 0 (0%) | 0 (0%) | 5 (21.7%) |  |