Table 4 Diagnostic accuracy stratified by definition of high flow nasal cannula failure
Nature of outcome | Number of studies | Number of patients | Number of cut-offs | sAUC | Optimal cut-off | Sensitivity at optimal cut-off | Specificity at optimal cut-off | Cut-off for 80% sensitivity | Cut-off for 80% specificity |
|---|---|---|---|---|---|---|---|---|---|
Intubation, mechanical ventilation, non-invasive ventilation, or death | 24 | 4790 | 44 | 0.771 (95% CI: 0.666–0.847) | 5.23 | 0.732 (95% CI: 0.578–0.846) | 0.690 (95% CI: 0.539–0.809) | 5.70 | 4.45 |
Intubation or mechanical ventilation | 13 | 3505 | 23 | 0.722 (95% CI: 0.535–0.845) | 5.18 | 0.634 (95% CI: 0.506–0.745) | 0.710 (95% CI: 0.566–0.821) | 7.06 | 4.20 |
Intubation, mechanical ventilation, or death | 9 | 1108 | 19 | 0.785 (95% CI: 0.588–0.891) | 4.90 | 0.730 (95% CI: 0.436–0.904) | 0.716 (95% CI: 0.422–0.897) | 5.24 | 4.48 |