Fig. 3

The PERSEVERENCE SA-AKI CART Model. Classification and regression analyses tree (CART) model to estimate risk of Day 3 sepsis-associated acute kidney injury based on serum creatinine criteria (D3 SA-AKI SCr) among patients with high- or intermediate-PERSEVERE-II mortality risk strata. The root node provides the total number of patients in the derivation cohort, and the number of those with and without D3 SA-AKI SCr, with the respective rates. Each daughter node provides the respective decision rule criterion and the number of those with and without D3 SA-AKI SCr, with the respective rates. The CART model had 6 terminal nodes (TN) which represent groups of patients who could not be separated further. Terminal nodes (TN) 1, 4, and 5 were deemed to have a high-risk of D3 SA-AKI SCr (≥ 71.4%); TN2, 3, and 6 were considered to have low-risk of D3 SA-AKI (< 11.8%), relative to rate of D3 SA-AKI Scr of 50.5% in the root note. Patients belonging to high or intermediate PERSEVERE-II mortality risk strata who had a Tie-2 concentration > 28,599 pg/mL (TN6) concentration had a low risk (8.7%) of D3 SA-AKI SCr. Among those with a Tie-2 concentrations ≤ 28,599 pg/mL, those without D1 SA-AKI could be further stratified once again based on Tie-2 concentrations; those with Tie-2 > 11,071 pg/mL had low-risk (11.8%) of D3 SA-AKI SCr (TN2) while those with Tie-2 ≤ 11,071 pg/mL had high-risk of D3 SA-AKI SCr (71.4%) (TN1). In contrast, those with Tie-2 ≤ 28,599 pg/mL and D1 SA-AKI, were further stratified based on Angpt-2/Tie-2 ratios. Patients with Angpt-2/Tie-2 < 0.35 had low-risk of D3 SA-AKI (33.3%, TN3). Those with high Angpt-2/Tie-2 ratios > 0.35 were further stratified based on sTM concentrations; those with sTM ≤ 11,830 pg/mL were high-risk of D3 SA-AKI SCr (72.0%, TN 4) while those with sTM > 11,820 pg/mL had a 100% risk of D3 SA-AKI SCr