Fig. 11
From: Moderate exercise-induced dynamics on key sepsis-associated signaling pathways in the liver
Sepsis increases the accumulation of nitrotyrosine (NT) protein adducts (peroxynitrite formation) in the Liver, Pre-exercise training attenuates these adducts levels. Enlarged part of the liver showing both central vein (CV) and portal vein (PV) tissue morphology. Male (A) and Female (B) rat liver sections show Hematoxylin–eosin (H&E) staining and nitrotyrosine (NT) protein adducts Immunostaining (brown stain cells marked with black arrowhead). H&E staining of the liver tissue sections showed extensive liver damage and inflammatory cell infiltration. Graph (C; ♂, n = 3) and (D; ♀,n = 3) represents the NT protein adducts (positive cells) density (μm−2) in the Liver tissue sections. G1 = sedentary, G2 = exercise-trained, G3 = exercise trained + sham surgery, G4 = CLP (untrained, tissue harvest at 24 h), G5 = CLP (trained, tissue harvest at 12 h), G6 = CLP (trained, tissue harvest at 24 h). Images scale bar = 90 μm