Table 2 Summary of ongoing randomised controlled trials included in the review
From: Definitions of massive transfusion in adults with critical bleeding: a systematic review
Study title (clinical trial number) | Date first posted | Country | Clinical setting | Intervention | Control | Total number of subjects | MT definition |
|---|---|---|---|---|---|---|---|
The efficacy and safety of preoperative misoprostol in blood-loss reduction during myomectomy (NCT03509168) | 26/4/18 | Uganda | Gynaecology | Misoprostol | No Misoprostol | 46 |  > 5 U blood |
Glove-loaded Foley's catheter tamponade for Cesarean section for placenta previa (NCT03570723) | 27/6/18 | Egypt | Obstetrics | Stepwise uterine devascularisation | A glove-loaded Foley's catheter | 120 |  > 3 U RBC |
Reducing blood loss during Cesarean hysterectomy for placenta accreta spectrum (NCT03570710) | 27/6/18 | Egypt | Obstetrics | TXA | Placebo | 80 |  > 4 U RBC |
Patient blood management for massive obstetric hemorrhage (NCT03784794) | 24/12/18 | Mexico | Obstetrics | TEG-guided transfusion | Standard algorithm | 100 |  ≥ 10 U RBC/24 h |
Anticipatory management vs standard management of postpartum haemorrhage (CN-01883655) | 25/7/11 | Sri Lanka | Obstetrics | Anticipatory management protocol | Standard management protocol | 252 |  > 5 U blood |
Clinical utility of thromboelastography in guiding prophylaxis of venous thromboembolism following trauma (NCT01050153) | 15/1/10 | USA | Trauma | TEG-guided thromboprophylaxis | Standard of care | 50 |  > 10 U RBC/6 h |
Freeze-dried plasma in the initial management of coagulopathy in trauma patients (NCT02750150) | 25/4/16 | France | Trauma | Freeze-dried plasma | FFP | 42 |  ≥ 4 U RBC/6 h |
Dose section phase II study to compare the inhibition of blood loss in patients undergoing primary heart surgery and treatment with the investigational drug MDCO-2010, the active comparator tranexamic acid, or placebo (CN-01801695) | 24/11/11 | Multinational | Cardiothoracic surgery | Antifibrinolytic MDCO-2010 | TXA and placebo | 44 |  > 5 U RBC/24 h |
Patient mobility and outcomes after cardiac surgery (NCT03806257) | 16/1/19 | USA | Cardiothoracic surgery | Enhanced physical therapy protocol | Control | 220 |  > 10 U RBC |
Intervention study about the additive infusion of concentrated fibrinogen preparation and the amount of blood transfusion for the massive hemorrhage case (UMIN000019027) | 15/9/15 | Japan | Trauma and gastrointestinal | Concentrated fibrinogen | No concentrated fibrinogen | 70 |  ≥ 10 U RBC |
Evaluating of the Hospital Universitario de Canarias massive transfusion protocol (NCT03074890) | 9/3/17 | Spain | Mixed | 1:1:1 ratio of RBC:FFP:PLT and conventional coagulation tests guiding resuscitation | No intervention | 30 |  ≥ 3 U RBC/1 h, 10 U RBC |