From: Definitions of massive transfusion in adults with critical bleeding: a systematic review
Study | Clinical setting | Country | Intervention | Control | Total number of subjects recruited | MT definition |
---|---|---|---|---|---|---|
Bulger 2008 | Trauma | USA | Hypertonic saline/dextran | Lactated Ringer solution | 209 |  ≥ 10 U RBC/24 h |
Hauser 2010 (CONTROL) | Trauma | Multinational | rFVIIa | Placebo | 573 |  ≥ 10 U RBC/24 h |
Nascimento 2013 (TRFL) | Trauma | Canada | Fixed-ratio transfusion | Laboratory-guided transfusion | 78 |  ≥ 10 U RBC/24 h |
Holcomb 2015 (PROPPR) | Trauma | Multinational | 1:1:1 RBC:FFP:PLT | 1:1:2 RBC:FFP:PLT | 680 |  ≥ 10 U RBC/24 h |
Innerhofer 2017 (RETIC) | Trauma | Austria | FFP | CFC | 100 |  ≥ 10 U RBC/24 h |
Sperry 2018 (PAMPer) | Trauma | USA | Plasma | Standard care | 501 |  ≥ 10 U RBC/24 h |
Baksaas-Aasen 2021(iTACTIC) | Trauma | Multinational | VHA | CCT | 396 |  ≥ 10 U RBC/24 h |
Bouzat 2021 (PROCOAG) | Trauma | France | Four-factor PCC | Saline | N/A |  ≥ 3 U RBC/1 h or ≥ 10 U RBC/24 h |
Jost 2022 (PREHO-PLYO) | Trauma | France | Plasma | Control | 134 |  ≥ 10 U RBC/24 h |
Moore 2018 (COMBAT) | Trauma | USA | Plasma | Saline | 125 |  > 10 U RBC |
Boffard 2005 | Trauma | Multinational | rFVIIa | Placebo | 277 |  > 20 U RBC |
Nathens 2006 | Trauma | USA | Leukoreduced transfusion | Non-leukoreduced | 268 |  > 6 U/24 h |
Martinaud 2019 (T-STORHM) | Trauma | France | Whole blood | Component therapy | N/A |  ≥ 4 U RBC/6 h |
Girdauskas 2010 | Cardiothoracic surgery | Germany | Treatment group | Control group | 56 |  > 20 U blood |
Vlasov 2020 (ALBICS) | Cardiothoracic surgery | Finland | 4% albumin | Ringer's acetate solution | N/A |  ≥ 5 U RBC |
Klein 2001 | Cardiothoracic surgery | Multinational | Roller pump | BioPump | 1000 |  > 5 U blood |
Locker 1997 | Orthopedic surgery | Austria | PGE1 | Placebo | 45 |  > 10 U RBC |
Ngichabes 2015 | Obstetrics /gynaecology | Kenya | TXA | Ornipressin | 34 |  > 5 U blood |
Reed 1986 | Mixed | USA | PLT | FFP | 33 |  ≥ 12 U blood/12 h |