Table 1 Characteristics of invasive mechanically ventilated patients with or without HHV-7 lung detection in the original cohort and the propensity score matching cohort
Variables | Original cohort | Matched cohort | ||||
|---|---|---|---|---|---|---|
HHV-7 negative (n = 676) | HHV-7 positive (n = 45) | P-value | HHV-7 negative (n = 75) | HHV-7 positive (n = 39) | P-value | |
Age, mean (SD) | 64.4 (15.5) | 59.2 (19.0) | 0.032 | 65.7 (14.7) | 64.3 (14.7) | 0.630 |
Male, n (%) | 470 (69.5) | 37 (82.2) | 0.102 | 62 (82.7) | 31 (79.5) | 0.872 |
Comorbidities, n (%) | ||||||
Diabetes mellitus | 151 (22.3) | 7 (15.6) | 0.380 | 11 (14.7) | 7 (17.9) | 0.853 |
Congestive heart failure | 80 (11.8) | 7 (15.6) | 0.613 | 9 (12.0) | 6 (15.4) | 0.830 |
Myocardial infarction | 30 (4.4) | 2 (4.4) | 1.000 | 2 (2.7) | 2 (5.1) | 0.888 |
Chronic pulmonary disease | 118 (17.5) | 8 (17.8) | 1.000 | 13 (17.3) | 8 (20.5) | 0.872 |
Liver disease | 50 (7.4) | 1 (2.2) | 0.312 | 5 (6.7) | 1 (2.6) | 0.625 |
Renal disease | 68 (10.1) | 5 (11.1) | 1.000 | 6 (8.0) | 3 (7.7) | 1.000 |
Solid tumor | 106 (15.7) | 5 (11.1) | 0.542 | 10 (13.3) | 5 (12.8) | 1.000 |
Hematological malignancy | 36 (5.3) | 2 (4.4) | 1.000 | 4 (5.3) | 2 (5.1) | 1.000 |
CTD | 28 (4.1) | 2 (4.4) | 1.000 | 3 (4.0) | 2 (5.1) | 1.000 |
Transplantation | 29 (4.3) | 2 (4.4) | 1.000 | 2 (2.7) | 2 (5.1) | 0.888 |
CAP, n (%) | 310 (45.9) | 16 (35.6) | 0.234 | 39 (52.0) | 15 (38.5) | 0.240 |
Immunosuppressive status, n (%) | 175 (25.9) | 12 (26.7) | 1.000 | 20 (26.7) | 11 (28.2) | 1.000 |
SOFA score at ICU admission, mean (SD) | 8.0 (3.5) | 7.8 (3.1) | 0.637 | 8.6 (3.4) | 7.7 (3.1) | 0.193 |
Respiratory score | 2.5 (1.1) | 2.6 (1.0) | 0.551 | 2.7 (1.0) | 2.7 (0.9) | 0.892 |
Coagulation score | 1.0 (1.2) | 0.8 (1.2) | 0.507 | 1.1 (1.3) | 1.0 (1.2) | 0.713 |
Liver score | 0.5 (0.9) | 0.4 (0.9) | 0.425 | 0.7 (1.1) | 0.4 (0.7) | 0.128 |
Cardiovascular score | 1.7 (0.9) | 1.3 (0.8) | 0.003 | 1.7 (0.9) | 1.3 (0.9) | 0.027 |
Neurological score | 1.7 (1.6) | 2.0 (1.7) | 0.234 | 1.8 (1.7) | 2.0 (1.7) | 0.663 |
Kidney score | 0.7 (1.2) | 0.7 (1.2) | 0.979 | 0.7 (1.1) | 0.5 (1.0) | 0.386 |
SOFA score at NGS time, mean (SD) | 9.2 (3.2) | 9.4 (3.1) | 0.649 | 9.3 (3.3) | 9.5 (3.3) | 0.784 |
Respiratory score | 3.1 (0.3) | 3.1 (0.3) | 0.622 | 3.1 (0.3) | 3.2 (0.4) | 0.767 |
Coagulation score | 1.2 (1.2) | 1.2 (1.3) | 0.804 | 1.2 (1.2) | 1.3 (1.3) | 0.591 |
Liver score | 0.6 (1.0) | 0.5 (0.9) | 0.838 | 0.7 (1.1) | 0.5 (0.8) | 0.297 |
Cardiovascular score | 1.8 (0.9) | 1.7 (0.9) | 0.333 | 1.7 (1.0) | 1.7 (0.9) | 0.793 |
Neurological score | 1.8 (1.6) | 2.0 (1.7) | 0.360 | 2.0 (1.7) | 2.2 (1.7) | 0.508 |
Kidney score | 0.7 (1.2) | 0.8 (1.3) | 0.602 | 0.7 (1.2) | 0.7 (1.1) | 0.859 |
Days from transfer to ICU to mNGS assay, mean (SD) | 5.7 (5.6) | 5.7 (5.7) | 0.974 | 5.0 (4.8) | 5.2 (5.2) | 0.791 |
Herpesviridae, n (%) | 340 (50.3) | 32 (71.1) | 0.011 | 35 (46.7) | 27 (69.2) | 0.036 |
Herpes simplex virus-1 | 206 (30.5) | 15 (33.3) | 0.813 | 15 (20.0) | 13 (33.3) | 0.180 |
Varicella zoster virus | 5 (0.7) | 0 (0.0) | 1.000 | 0 (0) | 0 (0) | NA |
Epstein–Barr virus | 123 (18.2) | 16 (35.6) | 0.008 | 15 (20.0) | 13 (33.3) | 0.180 |
Cytomegalovirus | 140 (20.7) | 19 (42.2) | 0.001 | 23 (30.7) | 15 (38.5) | 0.530 |
Human herpesvirus-6B | 12 (1.8) | 2 (4.4) | 0.485 | 1 (1.3) | 1 (2.6) | 1.000 |
Hospital LOS, mean (SD) | 30.4 (29.3) | 30.7 (24.0) | 0.942 | 26.8 (21.3) | 28.3 (23.0) | 0.728 |
28-day mortality, n (%) | 272 (40.2) | 18 (40.0) | 1.000 | 27 (36.0) | 18 (46.2) | 0.395 |