The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies

Table 4 Association of iatrogenic versus spontaneous hypoglycemia with outcome, as compared to no hypoglycemia

	Working memory	Planning and organization	Metacognition
T-Score, mean (SD)¹
No hypoglycemia	51.4 (11.1)	49.9 (10.2)	50.1 (10.9)
Iatrogenic hypoglycemia	52.8 (11.9)	52.4 (10.6)	52.3 (11.6)
Spontaneous or recurrent hypoglycemia	59.1 (13.2)	56.3 (14.8)	56.0 (14.9)
Univariable comparison, P-value
Overall	0.008	0.032	0.092
Spontaneous vs. no hypoglycemia	0.002	0.023	0.042
Iatrogenic vs. no hypoglycemia	0.59	0.16	0.37
Spontaneous vs. iatrogenic hypoglycemia	0.043	0.32	0.32
Multivariable P-value²
Overall	0.012	0.052	0.094
Spontaneous vs. no hypoglycemia	0.003	0.022	0.040
Iatrogenic vs. no hypoglycemia	0.45	0.29	0.36
Spontaneous vs. iatrogenic hypoglycemia	0.090	0.33	0.36

¹Higher scores reflect worse performance
²Multivariable linear regression analyses are adjusted for age, sex, treatment center, randomization group, pediatric index of mortality (PIM3 score) at time of admission, Screening Tool for Risk on Nutritional Status and Growth (STRONGkids) risk level at time of admission, diagnostic category, history of malignancy, predefined syndrome, race, geographic origin, language, parental educational level, parental occupational level, parental smoking before admission, left-hand preference, mean morning blood glucose, SD of all glucose measurements in PICU, and duration of PICU stay. As no patient had diabetes, diabetes was not included in the multivariable model

ISSN: 1364-8535