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Table 1 Baseline characteristics

From: Time to treatment and mortality for clinical sepsis subtypes

 

All

Clinical Sepsis Subtype

⍺

β

γ

δ

No. (%)

55,169

18,880 (34)

16,381 (30)

10,704 (19)

9,204 (17)

Patient demographics

 Age at admission, med. [IQR]

72 [60–83]

63 [51–75]

80 [71–87]

73 [62–84]

72 [61–83]

 Sex, No. (%)

  Male

28,636 (52)

10,549 (56)

7,847 (48)

4,678 (44)

5,382 (60)

  Female

26,533 (48)

8,331 (44)

8,534 (52)

6,026 (56)

3,642 (40)

 Race, No. (%)

  White

36,634 (66)

12,019 (64)

11,451 (70)

7,401 (69)

5,763 (63)

  Black

9,308 (17)

3,458 (18)

2,554 (16)

1,533 (14)

1,763 (19)

  Asian

2,461 (4.5)

768 (4.1)

684 (4.2)

537 (5.0)

472 (5.1)

  Othera

6,766 (12)

2,635 (14)

1,692 (10)

1,233 (12)

1,206 (13)

 Admission source, No. (%)

  Home

38,128 (69)

14,069 (75)

10,187 (62)

7,628 (71)

6,244 (68)

  Skilled nursing facility

14,458 (26)

3,867 (21)

5,451 (33)

2,526 (24)

2,614 (28)

  Otherb

2,583 (4.7)

944 (5.0)

743 (4.5)

550 (5.1)

346 (3.8)

Coexisting condition, No. (%)

  Chronic respiratory failure

5,704 (10)

795 (4.2)

3,195 (20)

687 (6.4)

1,027 (11)

  Congestive heart failure

10,968 (20)

1,510 (8.0)

6,452 (39)

1,449 (14)

1,557 (17)

  End-stage renal disease

5,426 (9.8)

880 (4.7)

3,043 (19)

603 (5.6)

900 (9.8)

Sepsis characteristics

 Site of infection, No. (%)

  Urinary

15,134 (27)

5,719 (30)

4,153 (25)

3,064 (29)

2,198 (24)

  Respiratory

22,048 (40)

6,826 (36)

7,628 (47)

3,991 (37)

3,603 (39)

  Gastrointestinal

5,586 (10)

1,504 (8.0)

1,422 (8.7)

1,411 (13)

1,249 (14)

  Otherc

12,401 (23)

4,831 (26)

3,178 (19)

2,238 (21)

2,154 (23)

  Positive blood cultures, No. (%)

8,111 (15)

2,264 (12)

1,881 (12)

1,977 (19)

1,989 (22)

  Lactated, mmol/L, med. [IQR]

2.7 [1.8–4.2]

2.2 [1.5–3.1]

2.3 [1.5–3.3]

2.9 [2.0–4.2]

7.0 [5.2–9.6]

  Septic shocke, No. (%)

24,182 (44)

4,188 (22)

9,353 (57)

4,315 (40)

6,326 (69)

  Hypotension statusf, No. (%)

  Fluid unresponsive

16,117 (29)

3,126 (17)

5,730 (35)

2,932 (27)

4,329 (47)

  Responsive to fluids

16,437 (30)

5,172 (27)

4,376 (26)

3,580 (33)

3,309 (36)

In-hospital Outcomes

     

  ICU admission, No. (%)

30,923 (56)

7,059 (37)

11,419 (70)

5,446 (51)

6,999 (76)

  Length of stay, days, med. [IQR]

8 [5–14]

7 [4–13]

9 [6–16]

8 [5–14]

8 [3–15]

  Mortality, No. (%)

11,998 (22)

1,905 (10)

4,450 (27)

1,867 (17)

3,776 (41)

  1. ICU intensive care unit, IQR interquartile range, med median, LOS length of stay
  2. aOther race corresponds to Chinese, Filipino, Hawaiian, American Indian/Alaskan, Asian, Hawaiian/Other Pacific Islander, Middle Eastern, Native American, or Pacific Islander
  3. bOther locations include clinic or unknown
  4. cOther sources include skin, central nervous system, and unknown
  5. dCorresponds to minimum or maximum values within 6 h of hospital admission
  6. eAs defined by Sepsis-2 guidelines
  7. fFluid unresponsive defined as hypotension or elevated lactate not responsive to fluids; Responsive to fluids defined as hypotension or elevated lactate responsive to fluid
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Critical Care

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