Skip to main content

Table 3 Clinical, EEG and laboratory variables associated with functional outcome

From: The association between the presence and burden of periodic discharges and outcome in septic patients: an observational prospective study

 

Functional outcome

Favourable (n = 55)

Unfavourable (n = 37)

Univariate

Multivariate

p value

p value

OR

CI 95%

Age (> 65y)

22 (40%)

22 (59%)

0.067

0.06

2.59

[0.96–7.02]

Female

18 (33%)

12 (32%)

0.97

–

  

APACHE II

20 [15–24]

26 [21–33]

0.02

–

  

non–neuro APACHE II

17 [10–23]

19 [14–25]

0.31

–

  

APACHE II (> 23)

20 (36%)

21 (57%)

0.054

0.5

1.39

[053–3.66]

CAM-ICU + 

18/47 (38%)

11/23 (49%)

0.45

–

  

CRS-R

22 [11–23]

3 [1–18]

 < 0.001

–

  

GCS

14 [11–15]

7 [3–14]

 < 0.001

–

  

Sedation

12 (22%)

18 (49%)

0.007

–

  

 Propofol dose (mg/kg/day)

17 [3–47]

25 [15–35]

0.25

–

  

 Propofol duration (day)

1 [1–2]

3 [2–4.5]

0.007

–

  

 Mdz dose (mg/kg/day)

0.6 [0.6–1.5]

0.2 [0.1–04]

0.07

–

  

 Mdz duration (day)

2 [2–3.5]

1.5 [1–1.5]

0.27

–

  

 Dxd dose (µg/kg/day)

7.1 [na]

7.9 [6–16.7]

1

–

  

 Dxd duration (day)

2 [na]

2 [1–3]

1

–

  

Vasoactive drugs

46 (84%)

30 (81%)

0.75

–

  

Mechanical ventilation

34 (62%)

30 (81%)

0.049

–

  

SAE

35 (64%)

31 (84%)

0.035

0.21

2.8

[0.66–6.52]

cEEG rhythmic and periodic patterns

 RDA

25 (45%)

23 (62%)

0.11

–

  

 PDs

8 (15%)

15 (41%)

0.005

0.02

3.82

[1.27–11.49]

 PDs burden

[0–46%]

[0–60%]

0.008

–

  

cEEG background

 Reactivity

48 (87%)

26 (70%)

0.044

–

  

 Sleep

36 (65%)

19 (51%)

0.17

–

  

 PDR

52 (95%)

30 (81%)

0.042

–

  

 High grade mSynek scale

11 (20%)

22 (60%)

 < 0.001

–

  

 SB/suppressed

0 (0%)

3 (8%)

0.06

–

  

 Discontinuous/Low voltage

4 (7%)

7 (19%)

0.09

–

  
  1. Data are presented as median [interquartile range] or count (percentage)
  2. APACHE-II Acute physiological and chronic health evaluation, Non-neuro APACHE-II APACHE II minus the GCS component, The APACHE-II > 23 represents the prevalence of APACHE scores above the median value of the study population (i.e., 22). CAM-ICU Confusion Assessment Method for the ICU, CRS-R The Coma Recovery Scale-Revised, Mdz Midazolam, Dxd Dexmedetomidine, SAE Sepsis-associated encephalopathy, ICU Intensive care unit, (c)EEG (continuous) electroencephalogram, RDA Rhythmic delta activity, PD Periodic discharges, PDR Posterior dominant rhythm, High grade mSynek scale High grade modified Synek scale defined as grade of III or more (please refer to Additional file 1: Table S1), SB Suppression-Burst, Discontinuous/Low Voltage/SB/suppressed background: please refer to text for definition. Mann–Whitney, Fisher's exact and χ2 tests were used to analyze differences in variables between groups, as appropriate. Multivariate logistic regression was performed. p < 0.05 was considered statistically significant and marked in bold in the table. After correction for disease severity, age and the presence of SAE, PDs occurrence was statistically associated with an unfavorable outcome (p = 0.02)
Back to article page

Critical Care

ISSN: 1364-8535