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Table 2 Clinical characteristics and EEG patterns associated with EEG reactivity

From: The association between the presence and burden of periodic discharges and outcome in septic patients: an observational prospective study

 

Reactivity

p value

Mostly present (n = 18)

Mostly present (n = 74)

Age

69 [48.5–74]

65 [59–73]

0.95

Female

10 (56%)

20 (27%)

0.021

APACHE-II

23 [19–27]

21 [16–30]

0.33

non-neuro APACHE-II

14.5 [9–20]

19 [13–25]

0.053

CRS-R

1 [0–5]

22 [6–23]

 < 0.001

GCS

3 [3–8]

14 [10–15]

 < 0.001

CAM-ICU + 

5/6 (83%)

24/64 (37.5%)

0.07

Sedation

14 (78%)

16 (22%)

 < 0.001

T°

37.8 [37.4–38.6]

37.4 [37.5–37.9]

0.06

WBC (× 103/mm3)

19.7 [14.5–32.6]

18.5 [12.5–25.6]

0.33

Creatinine (mg/dl)

1.58 [1.33–2.63]

1.5 [1.-3.09]

0.6

Bilirubin (mg/dl)

1.2 [0. 9–2]

0.9 [0.5–1.6]

0.12

NSE (ng/ml)

32.7 [21.2–41.8]

17.3 [13.6–27.1]

0.012

Acute kidney injury

13 (72%)

50 (67%)

0.7

Chronic kidney injury

3 (17%)

7 (9%)

0.4

Acute liver injury

6 (33%)

20 (27%)

0.59

EEG PDs

9 (50%)

14 (19%)

0.006

EEG RDA

13 (72%)

35 (47%)

0.06

High grade mSynek scale

15 (83%)

18 (24%)

 < 0.001

  1. Data are presented as median [interquartile range] or count (percentage)
  2. APACHE-II Acute physiological and chronic health evaluation, Non-neuro APACHE-II APACHE II minus the GCS component, CRS-R The Coma Recovery Scale-Revised, GCS Glasgow coma scale, CAM-ICU The Confusion Assessment Method for the ICU, considered as positive if patients presented with delirium and RASS > -4, T° Body temperature, WBC White blood cells count, NSE Neuron-specific enolase, PDs Periodic discharges, RDA Rhythmic delta activity, PDR Posterior dominant rhythm, High grade mSynek scale High grade modified Synek scale defined as grade of III or more (please refer to Additional file 1: Table S1). Mann–Whitney, Fisher’s exact and χ2 tests were used to analyze differences in variables between groups, as appropriate. p < 0.05 was considered statistically significant and marked in bold in the table. For the T° and the other laboratories variables (WBC, creatinine, bilirubin, NSE), the highest value during the ICU period was considered
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Critical Care

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