Table 3 Univariate analysis and logistic regression analysis for 12 m mortality
Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
OR (95% CI) | p-value | OR (95% CI) | p-value | |
Demographic | ||||
Male | 1.10 (0.97–1.26) | 0.14 | 1.11 (1.03–1.19) | 0.01 |
Age | 1.03 (1.03–1.04) | < 0.001 | 1.17 (1.07–1.28) | 0.01 |
Charlson comorbidity index | 1.28 (1.25–1.31) | < 0.001 | 1.71 (1.55–1.87) | < 0.001 |
Laboratory variables at admission | ||||
Haematocrit min, % | 0.96 (0.95–0.97) | < 0.001 | 1.17 (1.04–1.33) | 0.01 |
Haemoglobin max, mg/dL | 0.85 (0.83–0.88) | < 0.001 | 0.69 (0.60–0.78) | < 0.001 |
Platelets min, cell/mm3 | 1.00 (1.00–1.00) | 0.84 | ||
WBC min, cell/mm3 | 1.01 (1.00–1.01) | 0.04 | 1.01 (0.94–1.09) | 0.76 |
WBC max, cell/mm3 | 1.00 (1.00–1.01) | 0.24 | ||
Anion gap max, mEq/L | 1.02 (1.01–1.03) | 0.01 | 0.99 (0.90–1.08) | 0.77 |
Bicarbonate min, mEq/L | 1.00 (0.99–1.01) | 0.9 | ||
BUN max, mg/dL | 1.01 (1.01–1.01) | < 0.001 | 1.11 (1.00–1.23) | 0.06 |
Calcium max, mEq/L | 1.06 (0.99–1.15) | 0.10 | 1.04 (0.96–1.12) | 0.38 |
Chloride min, mEq/L | 0.99 (0.98–1.00) | 0.04 | 0.90 (0.84–0.97) | 0.007 |
Creatinine min, mEq/L | 1.03 (0.98–1.08) | 0.18 | 0.73 (0.66–0.82) | < 0.001 |
Glucose min, mg/dL | 1.00 (1.00–1.00) | 0.50 | ||
Sodium max, mEq/L | 1.00 (0.99–1.01) | 0.95 | ||
Potassium max, mEq/L | 1.11 (1.04–1.19) | 0.01 | 0.98 (0.90–1.06) | 0.56 |
Lymphocytes max, cell/mm3 | 1.01 (0.99–1.02) | 0.42 | ||
Neutrophils max, cell/mm3 | 1.00 (0.99–1.01) | 0.58 | ||
INR max | 1.24 (1.17–1.31) | < 0.001 | 1.33 (0.98–1.79) | 0.06 |
PT max, sec | 1.02 (1.01–1.02) | < 0.001 | 0.91 (0.67–1.23) | 0.53 |
PTT max, sec | 1.01 (1.00–1.01) | < 0.001 | 1.06 (0.98–1.14) | 0.16 |
Urine output, mL | 1.00 (1.00–1.00) | < 0.001 | 0.85 (0.78–0.92) | < 0.001 |
Interventions | ||||
HFNC | 0.98 (0.68–1.42) | 0.92 | ||
Invasive ventilation | 1.05 (0.92–1.20) | 0.48 | ||
Non-invasive ventilation | 1.09 (0.79–1.51) | 0.61 | ||
Severity | ||||
SAPS II | 1.05 (1.04–1.05) | < 0.001 | 1.25 (1.13–1.37) | < 0.001 |
Respiratory failure | 1.59 (1.39–1.81) | < 0.001 | 1.14 (1.06–1.23) | 0.01 |
Septic shock | 2.10 (1.81–2.43) | < 0.001 | 1.26 (1.17–1.37) | < 0.001 |
ARDS | 1.18 (0.64–2.16) | 0.60 | ||
Antibiotic treatment | ||||
Macrolide-based | 0.76 (0.66–0.88) | < 0.001 | 0.84 (0.78–0.91) | < 0.001 |
Quinolones | 0.81 (0.69–0.96) | 0.02 | 0.94 (0.87–1.01) | 0.10 |
Aetiology | ||||
No aetiology | 1.40 (1.21–1.62) | < 0.001 | 1.10 (1.02–1.19) | 0.02 |
Atypical bacteria | 1.28 (1.00–1.63) | 0.05 | 1.02 (0.95–1.10) | 0.52 |
Typical bacteria | 0.93 (0.69–1.24) | 0.61 | ||
P. aeruginosa or MRSA | 1.17 (0.97–1.40) | 0.10 | 1.02 (0.95–1.10) | 0.56 |
Fungi | 1.12 (0.60–2.07) | 0.72 | ||
Virus | 0.0 (0.00–0.00) | 1.00 | ||