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Table 1 Baseline characteristics of the study groups

From: Hypertonic sodium lactate infusion reduces vasopressor requirements and biomarkers of brain and cardiac injury after experimental cardiac arrest

Variable

Group

p value

Control (n = 11)

Intra-arrest (n = 12)

Post-ROSC (n = 11)

Male, n (%)

8 (72)

6 (50)

6 (54)

0.51

Weight, Kg

47.9 (5.8)

50.3 (6.2)

51 (7.1)

0.47

Temperature, °C

38.0 (0.8)

37.8 (0.7)

37.4 (0.8)

0.19

Arterial pH

7.51 (0.03)

7.49 (0.02)

7.49 (0.02)

0.36

Arterial lactate, mmol/L

1.3 (0.3)

1.1 (0.2)

1.5 (0.4)

0.06

Arterial glucose, g/dl

112.5 (31.7)

97.0 (16.3)

106.8 (13.1)

0.24

P/F

435.7 (57.3)

454.3 (68.0)

482.4 (69.7)

0.25

PaCO2, mmHg

41.6 (3.1)

43.0 (1.7)

41.2 (4.0)

0.34

Na+, mmol/L

133.4 (2.37)

134.6 (3.5)

135.9 (5.3)

0.36

K+, mmol/L

3.8 (0.3)

3.7 (0.1)

3.7 (0.3)

0.27

Cl−, mmol/L

100.7 (1.5)

101.8 (2.2)

103.2 (5.0)

0.21

Base excess, mEq/L

9.0 (3.0)

8.5 (1.1)

7.7 (2.3)

0.45

Osmolarity, osm/L

268.5 (3.2)

269.7 (6.9)

272.6 (10.2)

0.43

MAP, mmHg

83 (12)

89 (12)

87 (11)

0.57

HR, bpm

87 (14)

105 (29)

100 (22)

0.22

CVP, mmHg

7.3 (3.2)

6.6 (3.2)

8.4 (3.3)

0.47

SvO2, %

60.8 (7.9)

63.3 (7.3)

68.2 (6.9)

0.15

CO, L/min

5.8 (1.1)

6.0 (1.3)

5.3 (0.5)

0.28

PPV, %

11.4 (1.8)

11.6 (3.5)

12.8 (2.7)

0.50

PCWP, mmHg

10.5 (2.9)

9.5 (3.1)

11.5 (3.1)

0.29

CPO, Watt

0.8 (0.3)

1.1 (0.3)

0.9 (0.1)

0.11

DO2, ml/min

624.5 (180.5)

688.7 (193.3)

608.7 (77.3)

0.48

VO2, ml/min

245.7 (93.5)

237.2 (65.7)

190.2 (74.6)

0.23

OER, %

39.4 (6.3)

36.7 (8.6)

31.0 (11.1)

0.09

*Diuresis, ml

600 (256–825)

600 (300–700)

600 (500–700)

0.95

*ICP, mmHg

8.0 (6.1–10.3)

12.6 (6.8–14.4)

10.1 (7.0–12.8)

0.31

*PbtO2, mmHg

33.2 (31.9–38.3)

32.5 (25.7–41.6)

40.1 (24.8–42)

0.40

Hemoglobin, g/dl

8.9 (0.7)

8.4 (0.7)

8.4 (0.6)

0.20

  1. Data are reported as mean (SD) or *median (IQR)
  2. Data are reported as mean (SD). P/F = ratio between partial arterial oxygen pressure and fraction of inspired oxygen; PaCO2 = arterial partial pressure of carbon dioxide; MAP = mean arterial pressure; HR = heart rate; CVP = central venous pressure; SvO2 = mixed venous oxygen saturation; CO = cardiac output; PPV = pulse pressure variation; PCWP = pulmonary capillary wedge pressure; CPO = cardiac power output; DO2 = oxygen delivery; VO2 = oxygen consumption; OER = oxygen extraction ratio; ICP = intracranial pressure; and PbtO2 = brain tissue oxygen pressure