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Retraction Note: Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis

Critical Care volume 27, Article number: 146 (2023) Cite this article

The Original Article was published on 22 February 2012

Retraction Note: Critical Care 2012, 16:R32 https://doi.org/10.1186/1364-8535-16-R32


The Editor in Chief retracted this article because of significant concerns regarding the Western blots in Figs. 2A–F and 3A–D which question the integrity of the data. The authors stated that some of these figures were created by cutting and splicing blots to show representative samples. However, the authors were unable to supply raw images or explain the similarity in appearance of the figures. The Editor-in-Chief therefore no longer has confidence in the integrity of the data in this article. Alessandra Bitto and Francesco Squadrito do not agree to this retraction. Letteria Minutoli, Antonio David and Natasha Irrera had not responded to correspondence from the editor about this retraction. The editor was not able to obtain a current email address for Mariagrazia Rinaldi and Francesco S. Venuti. Allessandra Bitto has stated that Domenica Altavilla is now deceased.

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Author notes

  1. Contributed equally: Alessandra Bitto, Letteria Minutoli and Antonio David.

Authors and Affiliations

  1. Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Via C. Valeria Gazzi, 98125, Messina, Italy

    Alessandra Bitto, Letteria Minutoli, Natasha Irrera, Mariagrazia Rinaldi, Francesco Squadrito & Domenica Altavilla

  2. Department of Neurosciences, Psychiatry and Anaesthesiology, University of Messina, Via C. Valeria Gazzi, 98125, Messina, Italy

    Antonio David & Francesco S. Venuti

Authors
  1. Alessandra Bitto
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  2. Letteria Minutoli
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  3. Antonio David
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  4. Natasha Irrera
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  5. Mariagrazia Rinaldi
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  6. Francesco S. Venuti
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  7. Francesco Squadrito
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  8. Domenica Altavilla
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Corresponding author

Correspondence to Francesco Squadrito.

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Bitto, A., Minutoli, L., David, A. et al. Retraction Note: Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis. Crit Care 27, 146 (2023). https://doi.org/10.1186/s13054-023-04440-7

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  • DOI: https://doi.org/10.1186/s13054-023-04440-7

Critical Care

ISSN: 1364-8535