Fig. 2
From: Altered intestinal microbiome and metabolome correspond to the clinical outcome of sepsis
Comparison of microbial alterations in sepsis patients and HCs. A Student’s t-test showing differences in the Shannon diversity index of fecal samples from sepsis patients (n = 38) and HCs (n = 19). Data represent the median and quartiles of each group; **p < 0.01. B PCoA of the sepsis and HC groups, with plots based on the Bray–Curtis distance. Each point represents a sample and the colors represent different groups. The results of the ANOSIM test to compare dissimilarity indexes among samples are shown above the plots. C Average relative proportions of the main phyla, families, and genera in the two groups. D LEfSe used to identify essential differences in bacterial abundance (family to species level) between the sepsis and HC groups. Only taxa with a significant LDA threshold value > 4 are shown. E Spearman’s correlation analysis to evaluate the abundance between the most common bacteria at the genus level in the two groups. Only correlations with a p value < 0.05 are shown. Color shading of nodes represents species abundance. Color gradation of lines represents the R value, with negative correlations shown in blue and positive correlations shown in red