Table 1 Characteristics of the study population
All patients (N = 219) | Controls (N = 104) | Intervention (N = 115) | p value | |
|---|---|---|---|---|
Age, years | 57 (± 14) | 59 (± 15) | 55 (± 13) | 0.07 |
Male gender, n (%) | 112 (51) | 49 (47) | 63 (55) | 0.28 |
GCS on admission | 8 (4–13) | 9 (5–13) | 7 (4–12) | 0.09 |
Etiology, n (%) | 0.16 | |||
SAH | 119 (54) | 51 (49) | 68 (59) | 0.13 |
ICH | 73 (33) | 42 (40) | 31 (27) | |
TBI | 25 (11) | 10 (10) | 15 (13) | |
Others | 2 (1) | 1 (1) | 1 (1) | |
Comorbidities, n (%) | ||||
Arterial Hypertension | 116 (56) | 56 (57) | 60 (55) | 0.78 |
Diabetes mellitus | 33 (16) | 14 (14) | 19 (17) | 0.57 |
Heart disease | 33 (16) | 12 (12) | 21 (19) | 0.19 |
COPD | 17 (8) | 8 (8) | 9 (8) | 0.99 |
Liver Cirrhosis | 8 (4) | 6 (6) | 2 (2) | 0.15 |
Chronic kidney disease | 10 (5) | 6 (6) | 4 (4) | 0.52 |
Previous neurological disease | 21 (10) | 9 (9) | 12 (11) | 0.82 |
Malignancies | 16 (8) | 10 (10) | 6 (6) | 0.30 |
Immunosuppression | 7 (3) | 4 (4) | 3 (3) | 0.71 |
EVD placement to sample collection, days | 1 (1–2) | 2 (1–2) | 1 (1–2) | 0.50 |
Admission to sample collection, days | 2 (1–2) | 2 (1–2) | 1 (1–2) | 0.50 |
Outcomes | ||||
ICU length of stay, days | 18 (12–25) | 17 (11–25) | 18 (13–27) | 0.12 |
ICU mortality, n (%) | 55 (25) | 15 (14) | 40 (35) | 0.001 |
GOS at discharge | 3 (2–4) | 3 (3–4) | 3 (1–3) | 0.001 |
GOS at 3 months | 3 (1–4) | 4 (2–5) | 3 (1–4) | 0.002 |