Fig. 2

iTTP patients’ skin microvascular endothelium-mediated reactivity assessed by laser Doppler flowmetry at baseline and after PE. Evolution of skin microvascular laser Doppler flowmetry value regarding the baseline flow index (A) and the response to Ach iontophoresis (Peak value (B) and AUC (C)), in iTTP patients at admission and after the two first PE. *P < 0.05, **P < 0.01, paired Wilcoxon signed-rank test at each time point versus admission value for. Abbreviations: PU, perfusion index; CTR, controls, iTTP, immune-mediated thrombocytopenic thrombotic purpura; PE, plasma exchange; AUC, area under curve; Ach, Acetylcholine