Clinical risk factors for increased respiratory drive in intubated hypoxemic patients

Table 2 Multivariate regression model describing independent clinical risk factors for increased P_0.1

Variable	Β	Increase ratio*	95% Wald confidence interval	P value
Determinants of respiratory drive
PaO₂/FiO₂ (mmHg)	− 0.002	0.998	0.997–0.999	0.004
Ventilatory ratio	0.431	1.538	1.267–1.867	< 0.001
Bilateral (ARDS) versus unilateral infiltrates	0.209	1.233	1.047–1.451	0.012
pHa	− 2.260	0.104	0.024–0.464	0.003
Clinically set PEEP (cmH₂O)	− 0.050	0.951	0.921–0.982	0.002
Adjusting factors
Female versus male sex	− 0.244	0.784	0.658–0.933	0.006
Age (years)	− 0.004	0.996	0.990–1.001	0.123
SAPS II score	− 0.004	0.996	0.991–1.001	0.138
PaCO₂ (mmHg)	− 0.027	0.973	0.963–0.984	< 0.001

ARDS: acute respiratory distress syndrome; PEEP: positive end-expiratory pressure; PS: pressure support; SAPS II: Simplified Acute Physiology Score II
*Increase ratio = exp(β)

ISSN: 1364-8535