Comparison of clinical outcomes between aggressive and non-aggressive intravenous hydration for acute pancreatitis: a systematic review and meta-analysis

Table 1 Study characteristics

First author (Ref)	Country	Study period	Severity^a	Age, mean years ± SD		Male, n (%)		Participants, n (%)
First author (Ref)	Country	Study period	Severity^a	Aggressive	Non-aggressive	Aggressive	Non-aggressive	Aggressive	Non-aggressive
de‑Madaria [26]	India, Italy, Mexico, Spain	2020/05–2021/09	Mild	56 ± 18	57 ± 17	54 (44.3)	68 (53.5)	122	127
Angsubhakorn [51]	Thailand	2019/08–2020/10	Mild	46 ± 15	45 ± 15	18 (81.8)	16 (72.7)	22	22
Liu [52]	China	2019/01–2020/06	Mild to moderately severe	45 ± 13	47 ± 12	36 (75)	44 (63.8)	48	69
Wang [53]	China	2017/06–2019/06	Mild	43 ± 1	42 ± 1	29 (55.8)	28 (53.8)	52	52
Cuéllar [50]	Mexico	2015/05–2016/10	Mild to moderately severe	37 ± 16	39 ± 15	13 (30.2)	18 (40)	43	45
Li [54]	China	2016/01–2017/12	Mild	44 ± 10	46 ± 13	36 (72)	27 (54)	50	50
Buxbaum [49]	U.S	2013/04–2015/11	Mild	44 ± 14	45 ± 12	21 (77.8)	24 (72.3)	27	33
Mao [48]	China	2006/09–2008/12	Severe	50 ± 15	49 ± 10	34 (60.7)	36 (61)	56	59
Mao [47]	China	2001/03–2007/12	Severe	51 ± 14	50 ± 12	N/A	N/A	36	40

First author (Ref)	Initial fluid protocol		Goal-directed therapy	Fluid volume on day 1 after trial entry
First author (Ref)	Aggressive	Non-aggressive		Aggressive	Non-aggressive
de‑Madaria [26]	20 ml/kg bolus then 3 ml/kg/hr	10 ml/kg bolus then 1.5 ml/kg/hr	Yes	5400 ml	3310 ml
Angsubhakorn [51]	20 ml/kg bolus then 3 ml/kg/hr	10 ml/kg bolus then 1.5 ml/kg/hr	Yes	4886 ml	3985 ml
Liu [52]	15 ml/kg bolus then 5 ml/kg/hr after vital sign stable	10 ml/kg bolus then 5 ml/kg/hr after vital signs stable	Yes	3618 ml	3310 ml
Wang [53]	20 ml/kg bolus then 3 ml/kg/hr for 1 week	10 ml/kg bolus then 1.5 ml/kg/hr for 1 week	No	N/A	N/A
Cuéllar [50]	20 mL/kg bolus, then 3 mL/kg/hr for the first 24 h and then 30 mL/kg for the next 24 h	1.5 mL/kg/ hr for the first 24 h and 30 mL/kg during the next 24 h	No	~ 6400 ml^b	~ 2795 ml^b
Li [54]	20 ml/kg bolus then 3 ml/kg/hr	10 ml/kg bolus then 1.5 ml/kg/hr	Yes	N/A	N/A
Buxbaum [49]	20 ml/kg bolus then 3 ml/kg/hr	10 ml/kg bolus then 1.5 ml/kg/hr	Yes	5600 ml	3900 ml
Mao [48]	As reference^c	As reference^c	Yes	4805 ml^d	3883 ml^d
Mao [47]	10–15 ml/kg/hr	5–10 ml/kg/hr	Yes	6855 ml^d	5841 ml^d

^aSeverity, severity of the acute pancreatitis
^bCalculated from the given fluid protocol
^cFluid protocol of Mao et al. 2010: H0 × TBW (kg) × 5% = Hg × V1; V1 = (H0/Hg) × TBW × 5% (Liters); H0: Hematocrit on admission; Hg: Goal hematocrit in unit time; TBW: total body weight (kg); V1: Amount of fluid administered to meet the goal HCT; V = V1 + (2.5 L/24 h × unit time (h)). Goal-HCT within 48 h was 34% and 35% in rapid hemodilution and slow hemodilution, respectively
^dThis study followed the mixed fluid type protocol (the ratio of crystalloid and colloid volumes: 2–3:1) as the intravenous hydration for acute pancreatitis. Only lists the amount of crystalloid fluid

ISSN: 1364-8535